0000950170-24-022108 | 10-K | XBRL Viewer | Crinetics Pharmaceuticals INC

Revenue Recognition - Schedule of Deferred Revenue Components (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Deferred Revenue Arrangement [Line Items]
Deferred revenues at beginning of period	$ 2,240
Unearned revenue from cash received during the period, excluding amounts recognized as revenue during the period	1,535	$ (8,341)	$ 0
Balance at end of period	2,056	2,240
Deferred revenue, non-current	4,750	6,101
Sanwa Kagaku Kenkyusho Co Ltd [Member]
Deferred Revenue Arrangement [Line Items]
Deferred revenues at beginning of period	8,341	0
Unearned revenue from cash received during the period, excluding amounts recognized as revenue during the period	0	8,341
Revenue recognized that was included in deferred revenues as of the beginning of the period	(1,535)	0
Balance at end of period	6,806	8,341	$ 0
Less deferred revenue, current	(2,056)	(2,240)
Deferred revenue, non-current	$ 4,750	$ 6,101

Organization and Basis of Presentation	12 Months Ended
Organization and Basis of Presentation	Dec. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization and Basis of Presentation	1. ORGANIZATION AND BASIS OF PRESENTATION Description of Business Crinetics Pharmaceuticals, Inc. (the “Company”) is a clinical-stage pharmaceutical company incorporated in Delaware on November 18, 2008 and based in San Diego, California. The Company is focused on the discovery, development and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. In January 2017, the Company established a wholly-owned Australian subsidiary, Crinetics Australia Pty Ltd (“CAPL”), in order to conduct various preclinical and clinical activities for its development candidates. Principles of Consolidation and Foreign Currency Transactions The consolidated financial statements include the accounts of the Company and CAPL. All intercompany accounts and transactions have been eliminated in consolidation. The functional currency of both the Company and CAPL is the U.S. dollar. Assets and liabilities that are not denominated in the functional currency are remeasured into U.S. dollars at foreign currency exchange rates in effect at the balance sheet date except for nonmonetary assets, which are remeasured at historical foreign currency exchange rates in effect at the date of transaction. Net realized and unrealized gains and losses from foreign currency transactions and remeasurement are reported in other income (expense), in the accompanying consolidated statements of operations and comprehensive loss and were not material for all periods presented. Segment Reporting Operating segments are identified as components of an enterprise about which discrete financial information is available for evaluation by the chief operating decision-maker ("CODM"), in making decisions regarding resource allocation and assessing performance. The Company views its operations and manages its business in one operating segment. Liquidity From inception, the Company has devoted substantially all of its efforts to drug discovery and development and conducting preclinical studies and clinical trials. The Company has a limited operating history and the sales and income potential of the Company’s business and market are unproven. Successful transition to attaining profitable operations is dependent upon achieving a level of revenues adequate to support the Company’s cost structure. The Company has experienced net losses and negative cash flows from operating activities since its inception and has an accumulated deficit of $653.7 million as of December 31, 2023. As of December 31, 2023, the Company had $558.6 million in unrestricted cash, cash equivalents and investment securities, which the Company believes is sufficient to meet its funding requirements for at least the next 12 months. The Company expects to continue to incur net losses for the foreseeable future and believes it will need to raise substantial additional capital to accomplish its business plan over the next several years. The Company plans to continue to fund its losses from operations and capital funding needs through a combination of equity offerings, debt financings or other sources, including potential collaborations, licenses and other similar arrangements. If the Company is not able to secure adequate additional funding, the Company may be forced to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible, or suspend or curtail planned programs. Any of these actions could materially harm the Company’s business, results of operations and prospects. There can be no assurance as to the availability or terms upon which such financing and capital might be available in the future.

Balance Sheet Details - Additional Information (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 1.1	$ 1.0	$ 0.9

Operating Lease - Schedule of Future Minimum Payments Under Non-cancellable Operating Leases (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Leases [Abstract]
2024	$ 4,491
2025	7,468
2026	6,795
2027	6,999
2028	7,209
Thereafter	50,975
Total future minimum lease payments	83,937
Less imputed interest	(32,209)
Total operating lease liability	$ 51,728
Operating Lease, Liability, Current, Statement of Financial Position [Extensible Enumeration]	Liabilities, Current
Operating Lease, Liability, Noncurrent, Statement of Financial Position [Extensible Enumeration]	Operating lease liability, non-current
Less operating lease liability, current	$ (4,173)	$ (1,051)
Operating lease liability, non-current	47,555	$ 2,024
Total operating lease liabilities	$ 51,728

Subsequent Event

12 Months Ended

Dec. 31, 2023

Subsequent Events [Abstract]

Subsequent Event

14. SUBSEQUENT EVENTS

Subsequent to December 31, 2023 and through February 28, 2024, the Company issued 1,223,775 shares of common stock in the ATM Offering for net proceeds of approximately $43.4 million, after deducting commissions.

On February 27, 2024, the Company entered into a stock purchase agreement with certain investors named therein (the “Purchasers”), pursuant to which the Company agreed to issue and sell to the Purchasers in a private placement an aggregate of 8,333,334 shares of its common stock at a price of $42.00 per share for aggregate gross proceeds of approximately $350 million, before deducting offering expenses payable by the Company (the “Private Placement”). The Private Placement is expected to close on March 1, 2024, subject to customary closing conditions. On February 27, 2024, the Company also entered into a registration rights agreement with the Purchasers, pursuant to which the Company agreed to register for resale the shares sold to the Purchasers in the Private Placement on the terms set forth therein.

Income Taxes - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Operating Loss Carryforwards [Line Items]
Federal operating loss carryforwards	$ 311,300
State operating loss carryforwards	228,600
Foreign operating loss carryforwards	1,700
Federal loss carryforwards	305,000
Research and development credit carryforwards	$ 37,663	$ 22,210
Operating loss and research and development credit carryforwards, limitations on use	These ownership changes may limit the amount of NOL and credit carryforwards that can be utilized to offset future taxable income and income tax, respectively. In general, an “ownership change” as defined by the tax code results from a transaction or series of transactions over a three-year period resulting in an ownership change of more than 50 percent of the outstanding stock of a company by certain stockholders or public groups. During 2020, the Company completed a study to assess whether an ownership change within the meaning of Section 382 had occurred for the time period prior to July 15, 2020.
Cumulative change in ownership percentage	50.00%
Decreases in unrecognized tax benefits	$ 0	0	$ 0
Accrual for interest or penalties	0		0
Recognized interest and penalties	0	$ 0	$ 0
California
Operating Loss Carryforwards [Line Items]
Research and development credit carryforwards	$ 9,500
Federal
Operating Loss Carryforwards [Line Items]
Operating loss carryforwards, future taxable income, offset percentage	80.00%
Research and development credit carryforwards	$ 16,300
Research and development credit carryforwards, begin to expire	2030
Federal \| Orphan Drug Credits
Operating Loss Carryforwards [Line Items]
Research and development credit carryforwards	$ 20,500
State
Operating Loss Carryforwards [Line Items]
State operating loss carryforwards	$ 800

Investment In Radionetics (Additional Information) (Details) - USD ($)	1 Months Ended		12 Months Ended
	Aug. 31, 2023	Oct. 31, 2021	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021	Feb. 27, 2024	Sep. 15, 2023	Aug. 01, 2023	Apr. 18, 2022	Oct. 15, 2021
Common stock, shares issued			68,175,000	53,877,000		8,333,334,000
Receivable for common stock issued			$ 253,000	$ 0
Common stock, shares outstanding	32,344,371		68,175,000	53,877,000
Additional Sales Milestones								$ 15,000,000
Stock issued under employee stock purchase plan, value			$ 2,291,000	$ 1,618,000	$ 1,021,000
Warrants to purchase shares of common stock, Exercise price, Per share			$ 18.96	$ 17.79
Due from radionetics			$ 100,000	$ 100,000
Reimbursement earned			100,000	400,000	$ 600,000
Investment in radionetics			470,000	$ 0
Board of Directors Chairman [Member]
Amount of annual retainer			$ 50,000
Restricted Stock [Member] \| Board of Directors Chairman [Member]
Common stock, shares issued			1,000,000
Vest ratably tenure			36 months
Radionetics Warrant [Member]
Additional common shares issued	3,407,285									3,407,285
Warrants to purchase shares of common stock, Exercise price, Per share	$ 0.00001
Fair value adjustment of warrants	$ 700,000
Radionetics Oncology Inc [Member] \| Radionetics Warrant [Member]
Common stock price per share				$ 0.2	$ 0.02					$ 0.02
Radionetics [Member]
Stock issued under employee stock purchase plan, value	5,000,000
Loss on equity method investment			$ 5,200,000	$ 1,000,000
Investment in radionetics			500,000
Radionetics [Member] \| Five A M Ventures And Frazier Healthcare Partners [Member]
Upfront noncash considerations		$ 1,100,000
Receivable for common stock issued		$ 1,000,000
Warrant Price		100,000
Noncash upfront fee as license revenues		$ 1,100,000
Sales and royalties milestones		$ 1,000,000,000
Sales to Date			$ 0
Common Stock [Member]
Common stock, shares issued		50,500,000
Additional common shares issued		3,407,285
Interest Rate		22.00%
Common stock price per share							$ 30.59		$ 22.22
Stock issued under employee stock purchase plan, value	$ 3,407,285
Warrants to purchase shares of common stock, Exercise price, Per share	$ 0.00001
Issuance of stock under Stock Purchase Plan, shares			147,000	129,000	91,000
Common Stock [Member] \| Nonconsolidated Investees, Other [Member]
Ownership percentage		64.00%
Common Stock [Member] \| Radionetics [Member]
Ownership percentage	31.00%		31.00%
Preferred Stock [Member]
Stock issued under employee stock purchase plan, value	$ 5,000,000
Issuance of stock under Stock Purchase Plan, shares	14,404,656
Preferred Stock [Member] \| Radionetics [Member]
Ownership percentage	55.00%		26.00%
Stock issued under employee stock purchase plan, value	$ 5,000,000
Fair value adjustment of warrants	700,000
Addition in equity method investment	$ 5,700,000

Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Current assets:
Cash and cash equivalents	$ 54,897	$ 32,672
Investment securities, amortized cost of $502.7 million at December 31, 2023 and $305.7 million at December 31, 2022	503,658	301,753
Prepaid expenses and other current assets	15,598	10,759
Total current assets	574,153	345,184
Property and equipment, net	10,881	3,500
Operating lease right-of-use asset	46,549	1,486
Derivative asset	0	668
Investment in radionetics	470	0
Restricted cash	1,300	1,301
Other assets	2,000	37
Total assets	635,353	352,176
Current liabilities:
Accounts payable and accrued expenses	23,196	15,351
Accrued compensation and related expenses	14,517	9,081
Deferred revenue	2,056	2,240
Operating lease liabilities	4,173	1,051
Total current liabilities	43,942	27,723
Operating lease liability, non-current	47,555	2,024
Deferred revenue, non-current	4,750	6,101
Total liabilities	96,247	35,848
Commitments and contingencies (Note 7)
Stockholders’ equity:
Preferred stock, $0.001 par; 10,000 shares authorized, no shares issued or outstanding at December 31, 2023 or 2022	0	0
Common stock and paid-in capital, $0.001 par; 200,000 shares authorized, 68,175 shares issued and outstanding at December 31, 2023; 53877 shares issued and outstanding at December 31, 2022	1,191,831	759,432
Accumulated other comprehensive (loss) income	977	(3,931)
Accumulated deficit	(653,702)	(439,173)
Total stockholders’ equity	539,106	316,328
Total liabilities and stockholders’ equity	$ 635,353	$ 352,176

Income Taxes - Schedule of Domestic and Foreign Pre-Tax Loss (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
Loss before income taxes - Domestic	$ (214,027)	$ (163,175)	$ (107,723)
Income (loss) before income taxes - Foreign	(502)	(743)	82
Loss before income taxes - Consolidated	$ (214,529)	$ (163,918)	$ (107,641)

- Definition

Amount of income (loss) from continuing operations, including income (loss) from equity method investments, before deduction of income tax expense (benefit), and income (loss) attributable to noncontrolling interest.

+ References

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Reference 7: http://www.xbrl.org/2003/role/disclosureRef
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+ Details

Investment Securities - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Investments, Debt and Equity Securities [Abstract]
Allowance For Credit Losses	$ 0	$ 0
Realized gains on securities	0	(86,000)	$ 2,000
Accrued interest receivable on available-for-sale securities	$ 3,100,000	$ 1,400,000

Equity Incentive Plans - Additional Information (Details) - USD ($) $ / shares in Units, $ in Millions			1 Months Ended		12 Months Ended
	Jan. 01, 2024	Feb. 28, 2015	Nov. 30, 2023	Jul. 31, 2018	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Total intrinsic value of options exercised					$ 16.2	$ 5.9	$ 5.1
Fair value of options vested					$ 37.0	$ 23.0	$ 16.3
ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Annual increase in the number of shares available for issuance					1.00%
Maximum percentage of eligible compensation to purchase common stock through payroll deductions				20.00%
Unrecognized Stock-Based Compensation Cost 3					$ 3.0
2018 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Plan expiration period				2028-07
Plan expiration term				10 years
Vesting period				4 years
Annual increase in the number of shares available for issuance					5.00%
Remaining shares available for issuance					2,619,124,000
2015 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Plan expiration term		10 years
Vesting period		4 years
2021 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Remaining shares available for issuance					2,300,511		0
Additional shares available for future issuance							1,500,000
Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted average grant date fair value, Grants in Period						$ 19.91
Weighted average grant date fair value, Vested						0
Weighted average grant date fair value, Granted							0
Unrecognized Stock-Based Compensation Cost 3					$ 12.2
Restricted Stock Units \| ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Unrecognized stock-based compensation cost					$ 93.6
Weighted-average period of unrecognized stock-based compensation cost expected to be recognized over remaining period					2 years 1 month 6 days
Weighted-average period of unrecognized stock-based compensation cost expected to be recognized over remaining period 3					1 year 4 months 24 days
Amended \| 2021 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Remaining shares available for issuance					5,000,000
Common Stock
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-average fair value of stock options granted to employees per share					$ 13.09	$ 14.5	$ 13.02
Common Stock \| ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Plan expiration date					Jan. 01, 2028
Additional shares available for future issuance	3,408,761,000
Shares reserved for issuance, authorized					1,591,597
Additional shares available for future issuance	681,752
Weighted-average fair value of stock options granted to employees per share					$ 11.49	$ 0.39	$ 12.52
Common Stock \| Restricted Stock Units
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Weighted-Average Period of Unrecognized Stock-Based Compensation Cost Expected to be Recognized Over Remaining Period 2					3 years
Common Stock \| Amended \| 2021 Plan
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Additional shares available for future issuance			7,500,000,000

Summary of Significant Accounting Policies - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Summary Of Significant Accounting Policies [Line Items]
Impairment losses of long-lived assets	$ 0	$ 0	$ 0
Australian Research and Development Tax Incentive \| Australian Taxation Office
Summary Of Significant Accounting Policies [Line Items]
Tax incentive receivable, reductions to research and development expense	$ 43,000	$ 800,000	$ 300,000
Computer and Software
Summary Of Significant Accounting Policies [Line Items]
Property and equipment, estimated useful life	3 years
Minimum [Member] \| Lab Equipment
Summary Of Significant Accounting Policies [Line Items]
Property and equipment, estimated useful life	3 years
Minimum [Member] \| Office Equipment
Summary Of Significant Accounting Policies [Line Items]
Property and equipment, estimated useful life	3 years
Maximum [Member] \| Lab Equipment
Summary Of Significant Accounting Policies [Line Items]
Property and equipment, estimated useful life	5 years
Maximum [Member] \| Office Equipment
Summary Of Significant Accounting Policies [Line Items]
Property and equipment, estimated useful life	5 years

Operating Lease - Additional Information (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Operating Leased Assets [Line Items]
Rent expense	$ 3,300	$ 1,000	$ 1,000
Operating lease weighted average remaining term	11 years 1 month 6 days	2 years 7 months 6 days
Operating lease right-of-use asset	$ 46,549	$ 1,486
Operating lease liabilities	$ 47,555	$ 2,024
2018 Operating Lease
Operating Leased Assets [Line Items]
Operating lease, initial term	7 years
Operating lease expiration period	2025-08
Operating lease, option to extend term	five years
Lessee,operating lease, discount rate	8.00%
Irrevocable letter of credit	$ 500
Weighted-average discount rate	8.60%	8.00%
2022 Operating Lease [Member]
Operating Leased Assets [Line Items]
Operating lease, option to extend term	The Company has (i) two options to extend the term of the 2022 Lease for an additional period of five years each, and (ii) a right of first offer on adjacent space to the new facility, subject to the terms and conditions of the 2022 Lease. The 2022 Lease commenced in 2023 when the building was ready and available for its intended use. As of the date of the recording of the 2022 Lease, the Company is not reasonably certain that these options will be exercised.
Lessee,operating lease, discount rate	8.60%
Irrevocable letter of credit	$ 800
Cash paid for operating lease liabilities	1,600	$ 1,200	$ 1,200
Right Of Use Assets And Lease Liabilities	$ 700
Operating Lease Description	Under the terms of the 2022 Lease, the Company's expected future monthly minimum lease payments of $0.5 million, with six months of rent abatement in the first year, start on the earlier of (i) the date which is ten months after substantial completion of demolition work, or (ii) the date of the substantial completion of improvements and first occupancy for business purposes, and the term expires on the date immediately preceding the one hundred thirty-seventh monthly anniversary of this lease payment start date. Lease payments are subject to annual 3% increases.
ExpectedFutureMonthly MinimumLeasePaymentWithAbatement	$ 500
Annual Increase in Lease Payments	3.00%
Right of use assets obtained in exchange for lease obligation	$ 47,000

Consolidated Statements of Cash Flows - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Operating activities:
Net Income (Loss)	$ (214,529)	$ (163,918)	$ (107,641)
Reconciliation of net loss to net cash used in operating activities:
Stock-based compensation	40,937	28,268	17,352
Depreciation and amortization	1,098	983	922
Noncash lease expense	1,210	406	340
Accretion of purchase discounts and amortization of premiums on investment securities, net	(6,271)	34	422
Noncash license revenues	(2,000)	0	(1,078)
Loss on equity method investment	5,198	1,010	0
Loss on disposal of property and equipment	6	0	0
Change in valuation of derivative asset	0	(600)	0
Other, net	0	0	(1)
Increase (decrease) in cash resulting from changes in:
Prepaid expenses and other assets	(4,523)	215	(4,361)
Accounts payable and accrued expenses, compensation and related expenses	14,648	10,994	6,293
Deferred revenue	(1,535)	8,341	0
Operating lease liabilities	(546)	(938)	(836)
Net cash used in operating activities	(166,307)	(115,205)	(88,588)
Investing activities:
Purchases of investment securities	(527,857)	(329,817)	(125,404)
Purchase of investment in Radionetics preferred stock	(5,000)	0	0
Maturities of investment securities	337,132	157,493	69,357
Purchases of property and equipment	(4,688)	(1,656)	(436)
Net cash used in investing activities	(200,413)	(173,980)	(56,483)
Financing activities:
Proceeds from issuance of common stock, net of $22.7 million (2023), $7.8 million (2022) and $12.9 million (2021) transaction costs	369,019	117,242	249,542
Proceeds from exercise of stock options	19,925	4,721	3,137
Net cash provided by financing activities	388,944	121,963	252,679
Net change in cash, cash equivalents and restricted cash	22,224	(167,222)	107,608
Cash, cash equivalents and restricted cash - beginning of period	33,973	201,195	93,587
Cash, cash equivalents and restricted cash - end of period	56,197	33,973	201,195
Components of cash, cash equivalents and restricted cash:
Cash and cash equivalents	54,897	32,672	200,695
Restricted cash	1,300	1,301	500
Cash, cash equivalents and restricted cash - end of period	56,197	33,973	201,195
Non-cash financing activity:
Private company shares received under licensing arrangements	2,000	0	1,010
Derivative asset obtained for Investment in Radionetics common stock	0	0	68
Exercise of Derivative asset for Investment in Radionetics common stock	668	0	0
Stock issued under Employee Stock Purchase Plan	2,291	1,618	1,021
Stock options exercised receivable	166	0	0
Common stock issued receivable	87	0	0
Accrued financing costs	26	0	0
Amounts accrued for purchases of property and equipment	872	0	130
Right-of-use asset obtained in exchange for new or modified lease obligations	46,273	0	0
Leasehold improvements paid by the lessor	2,925	0	0
Change in unvested stock liability	$ 0	$ 2	$ 21

Balance Sheet Details - Components of Property and Equipment, Net (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Property Plant And Equipment [Line Items]
Property and equipment	$ 15,949	$ 7,584
Less accumulated depreciation and amortization	(5,068)	(4,084)
Total	10,881	3,500
Leasehold Improvements
Property Plant And Equipment [Line Items]
Property and equipment	9,837	3,516
Lab Equipment
Property Plant And Equipment [Line Items]
Property and equipment	4,253	3,168
Office Equipment
Property Plant And Equipment [Line Items]
Property and equipment	1,854	859
Computers and Software
Property Plant And Equipment [Line Items]
Property and equipment	$ 5	$ 41

Summary of Significant Accounting Policies (Tables)

12 Months Ended

Dec. 31, 2023

Accounting Policies [Abstract]

Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Net Loss Per Share

Potentially dilutive securities (in common stock equivalent shares) not included in the calculation of diluted net loss per share because to do so would be anti-dilutive are as follows (in thousands):


	Year ended December 31,
	2023		2022		2021
Stock options		12,627		9,757		6,554
Restricted stock units		814		290		—
Employee stock purchase plan		302		282		207
Unvested common stock subject to repurchase		—		—		1
Total		13,743		10,329		6,762

Consolidated Statements of Cash Flows (Parenthetical) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Statement of Cash Flows [Abstract]
Transaction costs	$ 22,735	$ 7,758	$ 12,964

Consolidated Statements of Operations and Comprehensive Loss - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Income Statement [Abstract]
Revenues	$ 4,013	$ 4,737	$ 1,078
Operating expenses:
Research and development	168,527	130,225	84,255
General and administrative	58,094	42,394	24,525
Total operating expenses	226,621	172,619	108,780
Loss from operations	(222,608)	(167,882)	(107,702)
Other income (expense):
Interest income	13,436	4,317	157
Change in fair value of derivative asset	0	600	0
Other income (expense), net	(159)	57	(96)
Total other income, net	13,277	4,974	61
Loss before equity method investment	(209,331)	(162,908)	(107,641)
Loss on equity method investment	(5,198)	(1,010)	0
Net loss	$ (214,529)	$ (163,918)	$ (107,641)
Net loss per share:
Net loss per share - basic	$ (3.69)	$ (3.15)	$ (2.8)
Net loss per share - diluted	$ (3.69)	$ (3.15)	$ (2.8)
Weighted average shares - basic	58,071	51,982	38,436
Weighted average shares - diluted	58,071	51,982	38,436
Other comprehensive income (loss):
Unrealized gain (loss) on investment securities	$ 4,908	$ (3,549)	$ (407)
Comprehensive net loss	$ (209,621)	$ (167,467)	$ (108,048)

Fair Value Measurements (Tables)

12 Months Ended

Dec. 31, 2023

Fair Value Disclosures [Abstract]

Schedule of Financial Assets Measured at Fair Value on Recurring Basis

Financial assets measured at fair value on a recurring basis as of December 31, 2023 and 2022 were as follows (in thousands):


	As of December 31, 2023
	Level 1		Level 2		Level 3		Total
Investment securities:
U.S. government obligations	$	280,209	$	—	$	—	$	280,209
Agency obligations		—		21,270		—		21,270
Certificates of deposit		—		2,440		—		2,440
Corporate debt securities		—		196,755		—		196,755
Commercial paper		—		2,984		—		2,984
Total assets measured at fair value	$	280,209	$	223,449	$	—	$	503,658


	As of December 31, 2022
	Level 1		Level 2		Level 3		Total
Investment securities:
U.S. government obligations	$	93,879	$	—	$	—	$	93,879
Agency obligations		—		58,851		—		58,851
Certificates of deposit		—		4,535		—		4,535
Corporate debt securities		—		142,994		—		142,994
Asset-backed securities		—		1,494		—		1,494
Total Investment securities		93,879		207,874		—		301,753
Derivative Assets:
Radionetics Warrant		—		—		668		668
Total assets measured at fair value	$	93,879	$	207,874	$	668	$	302,421

Schedule of Derivative Assets at Fair Value [Table Text Block]

The following is the Level 3 activity for the Company’s derivative asset:


	Year Ended December 31,
	2023			2022
Derivative asset at beginning of period	$	668		$	68
Gain on change in fair value of derivative asset		—			600
Exercise of derivative asset		(668	)		—
Balance at end of period	$	—		$	668

Pay vs Performance Disclosure - USD ($) $ in Thousands	12 Months Ended
Pay vs Performance Disclosure - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Pay vs Performance Disclosure
Net Income (Loss)	$ (214,529)	$ (163,918)	$ (107,641)

- Definition

The portion of profit or loss for the period, net of income taxes, which is attributable to the parent.

+ References

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+ Details

Income Taxes - Schedule of Reconciliation of Income Tax Expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
Expected income tax benefit at federal statutory rate	$ (45,051)	$ (34,423)	$ (22,605)
State income tax benefit, net of federal benefit	(797)	(128)	(7,083)
Change in valuation allowance	59,951	39,733	34,495
R&D credit	(18,179)	(10,918)	(7,117)
Stock-based compensation	1,241	781	1,196
Australian tax incentive	35	266	27
State rate change	44	3,243	(8)
Uncertain tax positions	2,691	0	0
Other	65	1,446	1,095
Provision for income taxes	$ 0	$ 0	$ 0

Balance Sheet Details

12 Months Ended

Dec. 31, 2023

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Balance Sheet Details

5. BALANCE SHEET DETAILS

Prepaid expenses and other current assets consisted of the following (in thousands):


	December 31, 2023		December 31, 2022
Prepaid clinical trial costs	$	2,574	$	2,567
Prepaid research and development costs		1,238		2,293
Australian tax incentive receivable		747		937
Prepaid insurance		857		939
Interest receivable		3,051		1,353
Due from Radionetics ("Note 9")		90		135
Landlord improvements receivable		5,210		605
Receivable for common stock issued		253		—
Other		1,578		1,930
Total	$	15,598	$	10,759

Property and equipment, net consisted of the following (in thousands):


	December 31, 2023			December 31, 2022
Leasehold improvements	$	9,837		$	3,516
Lab equipment		4,253			3,168
Office equipment		1,854			859
Computers and software		5			41
Property and equipment		15,949			7,584
Less accumulated depreciation and amortization		(5,068	)		(4,084	)
Total	$	10,881		$	3,500

Depreciation and amortization expense was $1.1 million, $1.0 million and $0.9 million for the years ended December 31, 2023, 2022 and 2021, respectively.

Accounts payable and accrued expenses consisted of the following (in thousands):


	December 31, 2023		December 31, 2022
Accounts payable	$	6,548	$	6,883
Accrued clinical trial costs		5,527		1,921
Accrued research and development costs		2,312		4,043
Accrued outside services and professional fees		1,726		1,810
Accrued landlord improvements		3,816		359
Other accrued expenses		3,267		335
Total	$	23,196	$	15,351

Balance Sheet Details (Tables)

12 Months Ended

Dec. 31, 2023

Organization, Consolidation and Presentation of Financial Statements [Abstract]

Components of Prepaid Expenses and Other Current Assets

Prepaid expenses and other current assets consisted of the following (in thousands):


	December 31, 2023		December 31, 2022
Prepaid clinical trial costs	$	2,574	$	2,567
Prepaid research and development costs		1,238		2,293
Australian tax incentive receivable		747		937
Prepaid insurance		857		939
Interest receivable		3,051		1,353
Due from Radionetics ("Note 9")		90		135
Landlord improvements receivable		5,210		605
Receivable for common stock issued		253		—
Other		1,578		1,930
Total	$	15,598	$	10,759

Components of Property and Equipment, Net

Property and equipment, net consisted of the following (in thousands):


	December 31, 2023			December 31, 2022
Leasehold improvements	$	9,837		$	3,516
Lab equipment		4,253			3,168
Office equipment		1,854			859
Computers and software		5			41
Property and equipment		15,949			7,584
Less accumulated depreciation and amortization		(5,068	)		(4,084	)
Total	$	10,881		$	3,500

Schedule of Accounts Payable and Accrued Expenses

Accounts payable and accrued expenses consisted of the following (in thousands):


	December 31, 2023		December 31, 2022
Accounts payable	$	6,548	$	6,883
Accrued clinical trial costs		5,527		1,921
Accrued research and development costs		2,312		4,043
Accrued outside services and professional fees		1,726		1,810
Accrued landlord improvements		3,816		359
Other accrued expenses		3,267		335
Total	$	23,196	$	15,351

Organization and Basis of Presentation - Additional Information (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2023 USD ($) Segment	Dec. 31, 2022 USD ($)
Organization And Basis Of Presentation [Line Items]
Number of operating segments \| Segment	1
Unrestricted cash, cash equivalents and investments securities	$ 558,600
Accumulated deficit	$ 653,702	$ 439,173
Minimum
Organization And Basis Of Presentation [Line Items]
Period of sufficient cash to meet its funding requirements	12 months

- Definition

Amount of accumulated undistributed earnings (deficit).

+ References + Details

Revenue Recognition

12 Months Ended

Dec. 31, 2023

Revenues [Abstract]

Revenue Recognition

8. REVENUE RECOGNITION

Sanwa Kagaku Kenkyusho Co., Ltd

On February 25, 2022, the Company and Sanwa Kagaku Kenkyusho Co., Ltd. ("Sanwa"), entered into a license agreement (the “Sanwa License”) whereby the Company granted Sanwa an exclusive license to develop and commercialize paltusotine in Japan.

Under the Sanwa License, Sanwa has the right to receive data obtained by the Company through certain paltusotine studies. The Company assessed the Sanwa License and concluded that Sanwa is a customer within the agreement. Sanwa will assume all costs associated with clinical trials and regulatory applications associated with these processes in Japan. Further, the Company retains all rights to develop and commercialize the product outside Japan. The Company also granted Sanwa the right to purchase supply of paltusotine for clinical and commercial requirements at cost plus a pre-negotiated percentage which was a market rate and therefore not a material right.

The Company determined that its performance obligations under the Sanwa License comprised the license and data exchange. Certain professional services, such as the Company's participation on committees, were deemed to be immaterial to the context of the contract.

In exchange, the Company received a $13.0 million nonrefundable, upfront payment and will be eligible to receive up to an additional $25.5 million in milestone payments related to the achievement of certain development, regulatory and commercial goals. In addition, upon market approval of paltusotine in Japan, the Company will be eligible to receive certain sales-based royalties. The Company determined that the transaction price amounted to the upfront payment of $13.0 million. As there

have been no sales to date, no sales-based milestones or royalties were recognized to date. Further, using the most-likely-method, the developmental milestone payments were considered fully constrained.

The control of the license was transferred to Sanwa at the inception of the contract and the Company does not have an ongoing performance obligation to support or maintain the licensed intellectual property. Revenue allocated to the data exchange obligation is recognized over time using the cost-to-cost measure as this method represents a faithful depiction of progress toward the ongoing paltusotine studies in the U.S. and related data transfer. Revenue is recognized on a gross basis as the Company is the principal.

Deferred revenue consisted of the following (in thousands):


	Year Ended December 31,
	2023			2022
Deferred revenues at beginning of period	$	8,341		$	—
Unearned revenue from cash received during the period, excluding amounts recognized as revenue during the period		—			8,341
Revenue recognized that was included in deferred revenues as of the beginning of the period		(1,535	)		—
Balance at end of period		6,806			8,341
Less deferred revenue, current		(2,056	)		(2,240	)
Deferred revenue, non-current	$	4,750		$	6,101

During the years ended December 31, 2023 and 2022, $1.5 million and $4.7 million, respectively, of the $13.0 million upfront payment was recognized as revenues in the accompanying consolidated statements of operations and comprehensive loss. Of the license revenues recognized during the year ended December 31, 2022, $1.5 million is related to the transfer of the license at the inception of the Sanwa License at a point in time, with the remaining amounts related to the data exchange performance obligation recognized over time. Deferred revenues are expected to be recognized over the duration of certain paltusotine studies conducted by the Company.

On June 14, 2022, the Company and Sanwa, entered into a clinical supply agreement (the "Sanwa Clinical Supply Agreement") whereby the Company is responsible for manufacturing and supplying certain materials to Sanwa for the completion of certain studies and trials under the Sanwa License. During the years ended December 31, 2023 and 2022, the Company recognized $0.4 million and $0.1 million, respectively, of revenues from the Sanwa Clinical Supply Agreement in the accompanying consolidated statements of operations and comprehensive loss.

Cellular Longevity, Inc., doing business as Loyal

On March 24, 2023, the Company and Cellular Longevity Inc., doing business as Loyal ("Loyal") entered into a license agreement (the “Loyal License”) whereby the Company granted Loyal an exclusive license to develop and commercialize CRN01941, a somatostatin receptor type 2 agonist, for veterinary use. In exchange the Company received a $0.1 million nonrefundable, upfront payment and preferred stock in Loyal valued at approximately $2.0 million. The Company will also be eligible to receive certain single-digit sales-based royalties if the licensed intellectual property is approved for veterinary use.

During the year ended December 31, 2023, the Company recognized $2.1 million of revenues from the Loyal License at the inception of the contract in the accompanying consolidated statements of operations and comprehensive loss. As of December 31, 2023, the shares of Loyal preferred stock issued and to be issued to the Company valued at $2.0 million is included in other assets in the accompanying consolidated balance sheets. The Loyal preferred stock does not have a readily determinable fair value and is recorded at cost less impairment. The Company assesses equity securities without a readily determinable fair value for changes in observable prices each period, noting none for the year ended December 31, 2023.

- Definition

The entire disclosure of revenue from contract with customer to transfer good or service and to transfer nonfinancial asset. Includes, but is not limited to, disaggregation of revenue, credit loss recognized from contract with customer, judgment and change in judgment related to contract with customer, and asset recognized from cost incurred to obtain or fulfill contract with customer. Excludes insurance and lease contracts.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 9
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-9

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 10
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-10

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 15
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-15

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 12
-Subparagraph (e)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-12

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 606
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Subparagraph (b)(2)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479806/606-10-50-13

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Name Accounting Standards Codification
-Topic 606
-Publisher FASB
-URI https://asc.fasb.org//606/tableOfContent

+ Details

Investment Securities (Tables)

12 Months Ended

Dec. 31, 2023

Investments, Debt and Equity Securities [Abstract]

Summary of Available-For-Sale Investment Securities Held by the Company

The Company reports its available-for-sale investment securities at their estimated fair values. The following is a summary of the available-for-sale investment securities held by the Company as of December 31, 2023 and 2022 (in thousands):


	As of December 31, 2023
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Market Value
Available-for-sale investment securities:
U.S. government obligations	$	279,577	$	731	$	(99	)	$	280,209
Agency obligations		21,271		16		(17	)		21,270
Certificates of deposit		2,450		2		(12	)		2,440
Corporate debt securities		196,399		526		(170	)		196,755
Commercial paper		2,984		—		—			2,984
Total	$	502,681	$	1,275	$	(298	)	$	503,658


	As of December 31, 2022
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Market Value
Available-for-sale investment securities:
U.S. government obligations	$	94,948	$	1	$	(1,070	)	$	93,879
Agency obligations		59,280		11		(440	)		58,851
Certificates of deposit		4,629		—		(94	)		4,535
Corporate debt securities		145,330		—		(2,336	)		142,994
Asset-backed securities		1,497		—		(3	)		1,494
Total	$	305,684	$	12	$	(3,943	)	$	301,753

Summary of Available-For-Sale Investment Securities By Contractual Maturity

As of December 31, 2023 and 2022, available-for-sale investment securities by contractual maturity were as follows (in thousands):


	As of December 31, 2023				As of December 31, 2022
	Amortized Cost		Fair Market Value		Amortized Cost		Fair Market Value
Available-for-sale investment securities:
Due in one year or less	$	414,031	$	414,406	$	246,276	$	243,542
Due after one year through five years		88,650		89,252		59,408		58,211
Total	$	502,681	$	503,658	$	305,684	$	301,753

Summary of Available-For-Sale Securities Investment

The following is a summary of the available-for-sale investment securities by length of time in a net loss position as of December 31, 2023 and 2022 (in thousands):


	As of December 31, 2023
	Less Than 12 Months					More Than 12 Months					Total
	Fair Market Value		Gross Unrealized Losses			Fair Market Value		Gross Unrealized Losses			Fair Market Value		Gross Unrealized Losses
Available-for-sale investment securities:
U.S. government obligations	$	10,400	$	(11	)	$	12,374	$	(88	)	$	22,774	$	(99	)
Agency obligations		8,170		(3	)		5,484		(14	)		13,654		(17	)
Certificates of deposit		244		(1	)		1,213		(11	)		1,457		(12	)
Corporate debt securities		3,595		—			32,612		(170	)		36,207		(170	)
Total	$	22,409	$	(15	)	$	51,683	$	(283	)	$	74,092	$	(298	)


	As of December 31, 2022
	Less Than 12 Months					More Than 12 Months					Total
	Fair Market Value		Gross Unrealized Losses			Fair Market Value		Gross Unrealized Losses			Fair Market Value		Gross Unrealized Losses
Available-for-sale investment securities:
U.S. government obligations	$	58,218	$	(493	)	$	29,412	$	(577	)	$	87,630	$	(1,070	)
Agency obligations		37,715		(209	)		7,269		(231	)		44,984		(440	)
Certificates of deposit		2,399		(47	)		2,136		(47	)		4,535		(94	)
Corporate debt securities		96,663		(1,399	)		43,330		(937	)		139,993		(2,336	)
Asset-backed securities		1,494		(3	)		—		—			1,494		(3	)
Total	$	196,489	$	(2,151	)	$	82,147	$	(1,792	)	$	278,636	$	(3,943	)

- Definition

Tabular disclosure of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale).

+ References

Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 9
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-9

Reference 2: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

Reference 3: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 4: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 5: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 6: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (aa)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 7: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (aaa)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 8: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-2

Reference 9: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

Reference 10: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

Reference 11: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (c)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

Reference 12: http://www.xbrl.org/2009/role/commonPracticeRef
-Topic 320
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 3
-Subparagraph (d)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147481800/320-10-50-3

+ Details

Subsequent Event - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands				12 Months Ended
	Feb. 28, 2024	Feb. 27, 2024	Aug. 13, 2019	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Subsequent Event [Line Items]
Common stock, shares issued		8,333,334,000		68,175,000	53,877,000
Common stock and paid-in capital, par value		$ 42		$ 0.001	$ 0.001
Proceeds from issuance of common stock, net		$ 350,000	$ 150,000	$ 369,019	$ 117,242	$ 249,542
Subsequent Event
Subsequent Event [Line Items]
Common stock, shares issued	1,223,775
Proceeds from issuance of common stock, net	$ 43,400

Employee Savings Plan

12 Months Ended

Dec. 31, 2023

Retirement Benefits [Abstract]

Employee Savings Plan

13. EMPLOYEE SAVINGS PLAN

The Company has a defined contribution 401(k) benefit plan (the “401(k) Plan”) for all eligible employees, effective May 1, 2016. The plan permits participants to contribute up to the amount allowable under federal limits of annual pre-tax compensation to the 401(k) Plan. Discretionary matching contributions to the 401(k) Plan are permitted in an amount equal to 50% of the first 6% of the employee’s taxable income up to a maximum of $3,000 per year. The Company accrued approximately $0.7 million, $0.5 million, and $0.3 million for matching contributions for the years ended December 31, 2023, 2022 and 2021, respectively.

Operating Lease

12 Months Ended

Dec. 31, 2023

Leases [Abstract]

Operating Lease

6. OPERATING LEASES

In February 2018, as amended in March 2018, the Company entered into a non-cancellable operating lease for a facility in San Diego, California (the "2018 Lease"). The 2018 Lease has an initial term of seven years which expires in August 2025, and the Company has an option to extend the term of the 2018 Lease for an additional five years, a termination option subject to early termination fees and an option to sublease the facility. The 2018 Lease is subject to base lease payments and additional charges for common area maintenance and other costs and includes certain lease incentives and tenant improvement allowances. The Company’s estimated incremental fully collateralized borrowing rate of 8.0% was used in its present value calculation as the 2018 Lease does not have a stated rate and the implicit rate was not readily determinable.

In 2022, the Company entered into a lease agreement for laboratory and office space in San Diego, California (the "2022 Lease").

Under the terms of the 2022 Lease, the Company's expected future monthly minimum lease payments of $0.5 million, with six months of rent abatement in the first year, start on the earlier of (i) the date which is ten months after substantial completion of demolition work, or (ii) the date of the substantial completion of improvements and first occupancy for business purposes, and the term expires on the date immediately preceding the one hundred thirty-seventh monthly anniversary of this lease payment start date. Lease payments are subject to annual 3% increases. The Company is also responsible for certain operating expenses and taxes during the term of the 2022 Lease. The 2022 Lease provides the Company with specified tenant improvement and landlord work allowances. The Company has (i) two options to extend the term of the 2022 Lease for an additional period of five years each, and (ii) a right of first offer on adjacent space to the new facility, subject to the terms and conditions of the 2022 Lease. The 2022 Lease commenced in 2023 when the building was ready and available for its intended use. As of the date of the recording of the 2022 Lease, the Company is not reasonably certain that these options will be exercised. During the year ended December 31, 2023, the Company recorded a right-of-use asset and corresponding lease liability in the accompanying consolidated balance sheets in connection with the 2022 Lease. The Company recorded $47.0 million for the Right-of-use asset obtained in exchange for the 2022 Lease.

In December 2023, the Company entered into a lease amendment to the 2022 Lease that moved the initial payment date and start of the hundred thirty-seventh month (discussed above) from September 2023 to November 2023. The amendment was a modification that did not result in a new contract as the modification did not provide the Company additional right-of-use assets. As a result, the Company recorded a $0.7 million reduction to right-of-use assets and lease liabilities in the accompanying consolidated balance sheets.

The Company’s estimated incremental fully collateralized borrowing rate of 8.6% was used in its present value calculation as the 2022 Lease does not have a stated rate and the implicit rate was not readily determinable. The rate was determined using a synthetic credit rating analysis.

Under the terms of the 2018 Lease and 2022 Lease, the Company provided the lessors with irrevocable letters of credit in the amounts of $0.5 million and $0.8 million, respectively. The lessors are entitled to draw on the letters of credit in the event of any default by the Company under the terms of the leases.

As of December 31, 2023, the Company's future minimum payments under non-cancellable operating leases, were as follows (in thousands):


Year ending December 31,	Minimum Payments
2024	$	4,491
2025		7,468
2026		6,795
2027		6,999
2028		7,209
Thereafter		50,975
Total future minimum lease payments		83,937
Less imputed interest		(32,209	)
Total operating lease liabilities		51,728
Less operating lease liabilities, current		(4,173	)
Operating lease liabilities, non-current	$	47,555

Operating lease cost was $3.3 million, $1.0 million, and $1.0 million for each of the years ended December 31, 2023, 2022 and 2021, respectively. As of December 31, 2023 and 2022, the Company’s weighted average remaining term was 11.1 years and 2.6 years, respectively. As of December 31, 2023 and 2022, the Company’s weighted-average discount rate was 8.6% and 8.0%, respectively.

Cash paid for amounts included in the measurement of lease liabilities for operating cash flow from operating leases was $1.6 million, $1.2 million, and $1.2 million during each of the years ended December 31, 2023, 2022 and 2021, respectively.

Investment Securities - Summary of Available-For-Sale Securities Investment (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Debt Securities, Available-for-Sale [Line Items]
Available-for-sale investment securities, Less than 12 Months, Fair Market Value	$ 22,409	$ 196,489
Available-for-sale investment securities, Gross Unrealized Loss, Less than 12 Months	(15)	(2,151)
Available-for-sale investment securities, More Than 12 Months, Fair Value	51,683	82,147
Available-for-sale investment securities, Gross Unrealized Loss, More Than 12 Months	(283)	(1,792)
Available-for-sale investment securities, Fair Market Value	74,092	278,636
Available-for-sale investment securities, Gross Unrealized Losses	(298)	(3,943)
Agency Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Available-for-sale investment securities, Less than 12 Months, Fair Market Value	8,170	37,715
Available-for-sale investment securities, Gross Unrealized Loss, Less than 12 Months	(3)	(209)
Available-for-sale investment securities, More Than 12 Months, Fair Value	5,484	7,269
Available-for-sale investment securities, Gross Unrealized Loss, More Than 12 Months	(14)	(231)
Available-for-sale investment securities, Fair Market Value	13,654	44,984
Available-for-sale investment securities, Gross Unrealized Losses	(17)	(440)
US Government Agencies Debt Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Available-for-sale investment securities, Less than 12 Months, Fair Market Value	10,400	58,218
Available-for-sale investment securities, Gross Unrealized Loss, Less than 12 Months	(11)	(493)
Available-for-sale investment securities, More Than 12 Months, Fair Value	12,374	29,412
Available-for-sale investment securities, Gross Unrealized Loss, More Than 12 Months	(88)	(577)
Available-for-sale investment securities, Fair Market Value	22,774	87,630
Available-for-sale investment securities, Gross Unrealized Losses	(99)	(1,070)
Certificates of Deposit [Member]
Debt Securities, Available-for-Sale [Line Items]
Available-for-sale investment securities, Less than 12 Months, Fair Market Value	244	2,399
Available-for-sale investment securities, Gross Unrealized Loss, Less than 12 Months	(1)	(47)
Available-for-sale investment securities, More Than 12 Months, Fair Value	1,213	2,136
Available-for-sale investment securities, Gross Unrealized Loss, More Than 12 Months	(11)	(47)
Available-for-sale investment securities, Fair Market Value	1,457	4,535
Available-for-sale investment securities, Gross Unrealized Losses	(12)	(94)
Corporate Debt Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Available-for-sale investment securities, Less than 12 Months, Fair Market Value	3,595	96,663
Available-for-sale investment securities, Gross Unrealized Loss, Less than 12 Months	0	(1,399)
Available-for-sale investment securities, More Than 12 Months, Fair Value	32,612	43,330
Available-for-sale investment securities, Gross Unrealized Loss, More Than 12 Months	(170)	(937)
Available-for-sale investment securities, Fair Market Value	36,207	139,993
Available-for-sale investment securities, Gross Unrealized Losses	$ (170)	(2,336)
Asset-Backed Securities [Member]
Debt Securities, Available-for-Sale [Line Items]
Available-for-sale investment securities, Less than 12 Months, Fair Market Value		1,494
Available-for-sale investment securities, Gross Unrealized Loss, Less than 12 Months		(3)
Available-for-sale investment securities, More Than 12 Months, Fair Value		0
Available-for-sale investment securities, Gross Unrealized Loss, More Than 12 Months		0
Available-for-sale investment securities, Fair Market Value		1,494
Available-for-sale investment securities, Gross Unrealized Losses		$ (3)

Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) (Parenthetical) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Statement of Stockholders' Equity [Abstract]
Issuance of common stock, net of transaction costs	$ 22,735	$ 7,758	$ 12,964

Consolidated Statements of Convertible Preferred Stock and Stockholders' Equity (Deficit) - USD ($) $ in Thousands	Total	Common Stock	Common stock and Paid-In Capital	Accumulated Other Comprehensive Income	Accumulated Deficit
Beginning Balance, Shares at Dec. 31, 2020		33,001,000
Beginning Balance at Dec. 31, 2020	$ 168,919		$ 336,508	$ 25	$ (167,614)
Issuance of common stock, net of transaction costs	249,542		249,542
Issuance of common stock, net of transaction costs, shares		14,126,000
Vesting of shares subject to repurchase	21		21
Vesting of shares subject to repurchase, shares		15,000
Exercise of stock options	3,137		3,137
Exercise of stock options, shares		364,000
Stock issued under employee stock purchase plan, value	1,021		1,021
Issuance of stock under Stock Purchase Plan, shares		91,000
Stock-based compensation	17,352		17,352
Comprehensive income (loss)	(407)			(407)
Net Income (Loss)	(107,641)				(107,641)
Ending Balance at Dec. 31, 2021	331,944		607,581	382	(275,255)
Ending Balance, Shares at Dec. 31, 2021		47,597,000
Issuance of common stock, net of transaction costs	117,242		117,242
Issuance of common stock, net of transaction costs, shares		5,626,000
Vesting of shares subject to repurchase	2		2
Vesting of shares subject to repurchase, shares		1,000
Exercise of stock options	4,721		4,721
Exercise of stock options, shares		524,000
Stock issued under employee stock purchase plan, value	1,618		1,618
Issuance of stock under Stock Purchase Plan, shares		129,000
Stock-based compensation	28,268		28,268
Comprehensive income (loss)	(3,549)			(3,549)
Net Income (Loss)	(163,918)				(163,918)
Ending Balance at Dec. 31, 2022	316,328		759,432	3,931	(439,173)
Ending Balance, Shares at Dec. 31, 2022		53,877,000
Issuance of common stock, net of transaction costs	369,080		369,080
Issuance of common stock, net of transaction costs, shares		12,787,000
Issuance of Common Stock Upon Vesting of Restricted Stock Units shares		81,000
Exercise of stock options	$ 20,091		20,091
Exercise of stock options, shares	1,282,603	1,283,000
Stock issued under employee stock purchase plan, value	$ 2,291		2,291
Issuance of stock under Stock Purchase Plan, shares		147,000
Stock-based compensation	40,937		40,937
Comprehensive income (loss)	(4,908)			(4,908)
Net Income (Loss)	(214,529)				(214,529)
Ending Balance at Dec. 31, 2023	$ 539,106		$ 1,191,831	$ (977)	$ (653,702)
Ending Balance, Shares at Dec. 31, 2023		68,175,000

Investment In Radionetics - Summary of primary inputs used in valuing the Radionetics common stock and the Radionetics Warrant (Details) - Radionetics Oncology, Inc.		12 Months Ended
	Oct. 15, 2021	Dec. 31, 2022	Dec. 31, 2021
Radionetics Warrant
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expected term		1 year 9 months 18 days	3 years
Expected volatility		116.60%	111.40%
Risk free interest rate		4.50%	0.70%
Marketability discount		51.00%	30.00%
Common Stock
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Expected term	3 years	1 year 9 months 18 days
Expected volatility	111.40%	116.60%
Risk free interest rate	0.70%	4.50%
Marketability discount	30.00%	51.00%

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 35
-Paragraph 1D
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480483/718-10-35-1D

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 35
-Paragraph 3
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480483/718-10-35-3

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)(1)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)(2)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480429/718-10-50-2

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 718
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)(3)
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+ Details

Consolidated Balance Sheets (Parenthetical) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Statement of Financial Position [Abstract]
Investment securities, amortized cost of $502.7 million at December 31, 2023 and $305.7 million at December 31, 2022	$ 502,681	$ 305,684
Preferred stock, par value	$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock and paid-in capital, par value	$ 0.001	$ 0.001
Common stock and paid-in capital, shares authorized	200,000,000	200,000,000
Common stock and paid-in capital, shares issued	68,175,000	53,877,000
Common stock and paid-in capital, shares outstanding	68,175,000	53,877,000

Investment Securities

12 Months Ended

Dec. 31, 2023

Investments, Debt and Equity Securities [Abstract]

Investment Securities

3. INVESTMENT SECURITIES


	As of December 31, 2023
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Market Value
Available-for-sale investment securities:
U.S. government obligations	$	279,577	$	731	$	(99	)	$	280,209
Agency obligations		21,271		16		(17	)		21,270
Certificates of deposit		2,450		2		(12	)		2,440
Corporate debt securities		196,399		526		(170	)		196,755
Commercial paper		2,984		—		—			2,984
Total	$	502,681	$	1,275	$	(298	)	$	503,658


	As of December 31, 2022
	Amortized Cost		Gross Unrealized Gains		Gross Unrealized Losses			Fair Market Value
Available-for-sale investment securities:
U.S. government obligations	$	94,948	$	1	$	(1,070	)	$	93,879
Agency obligations		59,280		11		(440	)		58,851
Certificates of deposit		4,629		—		(94	)		4,535
Corporate debt securities		145,330		—		(2,336	)		142,994
Asset-backed securities		1,497		—		(3	)		1,494
Total	$	305,684	$	12	$	(3,943	)	$	301,753

As of December 31, 2023 and 2022, available-for-sale investment securities by contractual maturity were as follows (in thousands):


	As of December 31, 2023				As of December 31, 2022
	Amortized Cost		Fair Market Value		Amortized Cost		Fair Market Value
Available-for-sale investment securities:
Due in one year or less	$	414,031	$	414,406	$	246,276	$	243,542
Due after one year through five years		88,650		89,252		59,408		58,211
Total	$	502,681	$	503,658	$	305,684	$	301,753

The following is a summary of the available-for-sale investment securities by length of time in a net loss position as of December 31, 2023 and 2022 (in thousands):


	As of December 31, 2023
	Less Than 12 Months					More Than 12 Months					Total
	Fair Market Value		Gross Unrealized Losses			Fair Market Value		Gross Unrealized Losses			Fair Market Value		Gross Unrealized Losses
Available-for-sale investment securities:
U.S. government obligations	$	10,400	$	(11	)	$	12,374	$	(88	)	$	22,774	$	(99	)
Agency obligations		8,170		(3	)		5,484		(14	)		13,654		(17	)
Certificates of deposit		244		(1	)		1,213		(11	)		1,457		(12	)
Corporate debt securities		3,595		—			32,612		(170	)		36,207		(170	)
Total	$	22,409	$	(15	)	$	51,683	$	(283	)	$	74,092	$	(298	)


	As of December 31, 2022
	Less Than 12 Months					More Than 12 Months					Total
	Fair Market Value		Gross Unrealized Losses			Fair Market Value		Gross Unrealized Losses			Fair Market Value		Gross Unrealized Losses
Available-for-sale investment securities:
U.S. government obligations	$	58,218	$	(493	)	$	29,412	$	(577	)	$	87,630	$	(1,070	)
Agency obligations		37,715		(209	)		7,269		(231	)		44,984		(440	)
Certificates of deposit		2,399		(47	)		2,136		(47	)		4,535		(94	)
Corporate debt securities		96,663		(1,399	)		43,330		(937	)		139,993		(2,336	)
Asset-backed securities		1,494		(3	)		—		—			1,494		(3	)
Total	$	196,489	$	(2,151	)	$	82,147	$	(1,792	)	$	278,636	$	(3,943	)

The Company does not intend to sell these available-for-sale securities, and it is not more likely than not that we will be required to sell these securities prior to recovery of their amortized cost basis. Based on the Company’s review of these available-for-sale securities, the unrealized losses as of December 31, 2023 and 2022 were primarily due to changes in interest rates and not due to increased credit risks associated with specific securities. The Company has no allowance for credit losses as of December 31, 2023 and 2022. No realized net gains or losses were recognized during the year ended December 31, 2023. During the years ended December 31, 2022, and 2021, the Company recognized ($86,000) and $2,000, respectively, of realized net gains (losses) in the accompanying statements of operations and comprehensive loss.

Accrued interest receivable on available-for-sale securities was $3.1 million and $1.4 million at December 31, 2023 and 2022, respectively. We have not written off any accrued interest receivable in any of the periods presented in the consolidated financial statements.

Equity Incentive Plans

12 Months Ended

Dec. 31, 2023

Share-Based Payment Arrangement [Abstract]

Equity Incentive Plans

11. EQUITY INCENTIVE PLANS

2021 Employment Inducement Incentive Award Plan

The Company adopted the 2021 Employment Inducement Incentive Award Plan (the "2021 Inducement Plan") in December 2021. The Company initially reserved 1,500,000 shares of the Company’s common stock for issuance pursuant to awards granted under the 2021 Inducement Plan. The terms of the 2021 Inducement Plan are substantially similar to the terms of the Company’s 2018 Incentive Award Plan (described below) with the exception that awards may only be made to an employee who has not previously been an employee or member of the board of directors of the Company if the award is in connection with commencement of employment. No awards were granted under the 2021 Inducement Plan during the year ended December 31, 2021. In 2022, the Company amended the 2021 Inducement Plan to increase the number of shares of the Company’s common stock available for future issuance under the 2021 Inducement Plan to 5,000,000 shares. In November 2023, the Company amended the 2021 Inducement Plan to increase the number of shares of the Company’s common stock available for future issuance under the 2021 Inducement Plan to 7,500,000 shares. As of December 31, 2023, 2,300,511 shares of common stock were available for future issuance under the 2021 Inducement Plan.

2018 Incentive Award Plan

The Company adopted the 2018 Incentive Award Plan (the “2018 Plan”) in July 2018. Under the 2018 Plan, which expires in July 2028, the Company may grant equity-based awards to individuals who are employees, officers, directors or consultants of the Company. Options issued under the 2018 Plan will generally expire ten years from the date of grant and vest over a four-year period. As of December 31, 2023, 2,619,124 shares of common stock were available for future issuance under the 2018 Plan.

The 2018 Plan contains a provision that allows annual increases in the number of shares available for issuance on the first day of each calendar year through January 1, 2028 in an amount equal to the lesser of: (i) 5% of the aggregate number of shares of the Company’s common stock outstanding on December 31 of the immediately preceding calendar year, or (ii) such lesser amount determined by the Company. Under this evergreen provision, on January 1, 2024 an additional 3,408,761 shares became available for future issuance under the 2018 Plan.

2015 Stock Incentive Plan

The Company adopted the 2015 Stock Incentive Plan (the “2015 Plan”) in February 2015, which provided for the issuance of equity awards to the Company’s employees, members of its board of directors and consultants. In general, options issued under this plan vest over four years and expire after 10 years. Subsequent to the adoption of the 2018 Plan, no additional equity awards can be made under the 2015 Plan.

2018 Employee Stock Purchase Plan

The Company adopted the 2018 Employee Stock Purchase Plan (the “ESPP”) in July 2018. The ESPP permits participants to purchase common stock through payroll deductions of up to 20% of their eligible compensation. As of December 31, 2023, 1,591,597 shares of common stock were available for issuance under the ESPP.

The ESPP contains a provision that allows annual increases in the number of shares available for issuance on the first day of each calendar year through January 1, 2028 in an amount equal to the lesser of: (i) 1% of the aggregate number of shares of the Company’s common stock outstanding on December 31 of the immediately preceding calendar year, or (ii) such lesser amount determined by the Company. Under this evergreen provision, on January 1, 2024, an additional 681,752 shares became available for future issuance under the ESPP.

Stock Awards

Stock Options

Activity under the Company’s stock option plans during the year ended December 31, 2023 was as follows:


				Weighted-		Weighted-		Aggregate
				Average		Average		Intrinsic
	Options			Exercise		Remaining		Value
	Outstanding			Price		Term (in years)		(000’s)
Balance on December 31, 2022		9,757,329		$	17.79
Granted		4,824,597		$	20.67
Exercised		(1,282,603	)	$	15.66
Forfeited and expired		(672,199	)	$	20.56
Balance on December 31, 2023		12,627,124		$	18.96		8.0	$	209,884
Vested and expected to vest on December 31, 2023		12,627,124		$	18.96		8.0	$	209,884
Exercisable on December 31, 2023		5,255,484		$	17.36		6.7	$	95,731

Aggregate intrinsic value is calculated as the difference at a specific point in time between the closing price of the Company’s common stock at December 31, 2023 and the exercise price of stock options that had exercise prices below the closing price.

The aggregate intrinsic value of options exercised during 2023, 2022 and 2021 was $16.2 million, $5.9 million and $5.1 million, respectively.

The total fair value of options vested during 2023, 2022 and 2021 was $37.0 million, $23.0 million and $16.3 million, respectively.

Restricted Stock Units

The Company’s restricted stock unit activity during the year ended December 31, 2023 was as follows:


				Weighted-
	Restricted Stock			Average
	Units			Grant Date
	Outstanding			Fair Value
Balance on December 31, 2022		290,311		$	19.88
Granted		666,621		$	19.62
Vested		(81,294	)	$	19.54
Forfeited		(62,004	)	$	19.77
Balance on December 31, 2023		813,634		$	19.71

The weighted average grant date fair value for restricted stock units granted during 2022 was $19.91. No restricted stock units vested in 2022. There were no restricted stock units granted or vested in 2021.

Fair Value of Stock Awards

The Company estimates the fair value of all stock option grants and the ESPP using the Black-Scholes option pricing model and recognizes forfeitures as they occur.

The following table summarizes the weighted average assumptions used to estimate the fair value of stock options granted under the Company’s stock option plans for the periods presented below:


Stock Option Awards	Year ended December 31,
	2023			2022			2021
Expected option term	6.0 years			6.1 years			6.0 years
Expected volatility		66	%		88	%		86	%
Risk free interest rate		4.1	%		2.8	%		1.0	%
Expected dividend yield		—	%		—	%		—	%

The weighted-average fair value of stock options awarded during the years ended December 31, 2023, 2022 and 2021 was $13.09, $14.50 and $13.02 per share, respectively.

The following table summarizes the weighted average assumptions used to estimate the fair value of the ESPP awards for the periods presented below:


ESPP	Year ended December 31,
	2023			2022			2021
Expected term	1.1 years			1.3 years			1.6 years
Expected volatility		66	%		87	%		91	%
Risk free interest rate		5.0	%		4.1	%		0.3	%
Expected dividend yield		—	%		—	%		—	%

The weighted-average fair value of awards under the ESPP during the years ended December 31, 2023, 2022 and 2021 was $11.49, $9.39 and $12.52 per share, respectively.

The key assumptions used in determining the fair value of equity awards, and the Company’s rationale, were as follows: (i) Expected term - the expected term for stock options represents the period that the stock options are expected to be outstanding and has been estimated using the simplified method, due to limited historical exercise behavior. The expected term using the simplified method is an average of the contractual option term and its vesting period; the expected term for awards granted under the ESPP represents the term the awards are expected to be outstanding; (ii) Expected volatility - Beginning in 2023, the Company determined that the volatility of its own market-traded shares best represents the expected volatility based on available historical data and, therefore, the expected volatility assumption for stock-based awards granted during the year ended December 31, 2023 is based on the historical volatility of the Company's common stock. During 2022 and 2021, the expected volatility assumption was based on volatilities of a peer group of similar companies in the biotechnology industry whose share prices are publicly available. The Company computed the historical volatility data using the daily closing prices for the selected companies’ shares during the period equivalent to the expected term of the Company’s stock-based awards; (iii) Risk-free interest rate - the risk-free interest rate is based on the U.S. Treasury yield in effect at the time of grant for zero coupon U.S. Treasury notes with maturities that approximate the expected terms of awards; and (iv) Expected dividend yield - the expected dividend yield assumption is zero as the Company has never paid dividends and has no present intention to do so in the future.

Restricted stock units are valued using the closing sale price of our common stock on the date of grant.

Stock-Based Compensation Expense

Stock-based compensation expense for the equity awards issued by the Company to employees and non-employees for the periods presented below was as follows (in thousands):


	Year ended December 31,
	2023		2022		2021
Included in research and development	$	22,633	$	15,078	$	9,654
Included in general and administrative		18,304		13,190		7,698
Total stock-based compensation expense	$	40,937	$	28,268	$	17,352

As of December 31, 2023, unrecognized stock-based compensation cost related to option awards, restricted stock units, and ESPP was $93.6 million, $12.2 million and $3.0 million, respectively, which is expected to be recognized over a remaining weighted-average period of approximately 2.1 years, 3.0 years and 1.4 years, respectively.

Employee Savings Plan - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Retirement Benefits [Abstract]
Description of contributions to the plan	Discretionary matching contributions to the 401(k) Plan are permitted in an amount equal to 50% of the first 6% of the employee’s taxable income up to a maximum of $3,000 per year
Employee's contributions to the plan	$ 3,000
Accrued matching contributions	$ 700,000	$ 500,000	$ 300,000
Defined contribution benefit plan, effective date	May 01, 2016

Document and Entity Information - USD ($) $ in Billions	12 Months Ended
Document and Entity Information - USD ($) $ in Billions	Dec. 31, 2023	Feb. 20, 2024	Jun. 30, 2023
Cover [Abstract]
Document Type	10-K
Amendment Flag	false
Document Period End Date	Dec. 31, 2023
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	FY
Trading Symbol	CRNX
Entity Registrant Name	Crinetics Pharmaceuticals, Inc.
Entity Central Index Key	0001658247
Current Fiscal Year End Date	--12-31
Entity Well-known Seasoned Issuer	Yes
Entity Current Reporting Status	Yes
Entity Voluntary Filers	No
Entity Filer Category	Large Accelerated Filer
Entity Shell Company	false
Entity Small Business	false
Entity Emerging Growth Company	false
Entity Common Stock, Shares Outstanding		69,596,202
Entity Public Float			$ 1.0
Entity Interactive Data Current	Yes
Title of 12(b) Security	Common Stock, par value $0.001 per share
Security Exchange Name	NASDAQ
Document Financial Statement Error Correction	false
Entity File Number	001-38583
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	26-3744114
Entity Address, Address Line One	6055 Lusk Boulevard
Entity Address, City or Town	San Diego
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	92121
City Area Code	858
Local Phone Number	450-6464
Document Annual Report	true
Document Transition Report	false
ICFR Auditor Attestation Flag	true
Documents Incorporated by Reference	Certain sections of the registrant’s definitive proxy statement for the 2024 annual meeting of stockholders to be filed with the Securities and Exchange Commission pursuant to Regulation 14A not later than 120 days after end of the fiscal year covered by this Form 10-K are incorporated by reference into Part III of this Form 10-K.
Auditor Firm ID	243
Auditor Name	BDO USA, P.C.
Auditor Location	San Diego

Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Deferred tax assets:
Net operating loss carryforwards	$ 81,828	$ 69,044
Capitalized research expenses	43,509	22,123
R&D and other tax credits	37,663	22,210
Stock-based compensation	12,207	8,168
Lease liability	10,889	648
Accrued expenses and other, net	5,350	4,208
Equity method investment	3,230	0
Total deferred tax assets	194,676	126,401
Deferred tax liabilities:
Right-of use asset	(9,799)	(313)
Equity method investment	0	(140)
Net of deferred tax liabilities	9,799	453
Less: valuation allowance	(184,877)	(125,948)
Net deferred tax assets	$ 0	$ 0

Fair Value Measurements - Schedule of Level 3 Derivative Asset fair value (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Fair Value, off-Balance-Sheet Risks, Disclosure Information [Line Items]
Exercise of Derivative asset for Investment in Radionetics common stock	$ 668	$ 0	$ 0
Fair Value, Inputs, Level 3 [Member]
Fair Value, off-Balance-Sheet Risks, Disclosure Information [Line Items]
Derivative asset at beginning of period	668	68
Gain on change in fair value of derivative asset	0	600
Exercise of Derivative asset for Investment in Radionetics common stock	(668)	0
Derivative asset Balance at end of period	$ 0	$ 668	$ 68

Revenue Recognition (Tables)

12 Months Ended

Dec. 31, 2023

Revenue Recognition and Deferred Revenue [Abstract]

Schedule of deferred revenue components

Deferred revenue consisted of the following (in thousands):


	Year Ended December 31,
	2023			2022
Deferred revenues at beginning of period	$	8,341		$	—
Unearned revenue from cash received during the period, excluding amounts recognized as revenue during the period		—			8,341
Revenue recognized that was included in deferred revenues as of the beginning of the period		(1,535	)		—
Balance at end of period		6,806			8,341
Less deferred revenue, current		(2,056	)		(2,240	)
Deferred revenue, non-current	$	4,750		$	6,101

Investment Securities - Summary of Available-For-Sale Investment Securities by Contractual Maturity (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Debt Securities, Available-for-Sale, Maturity, Allocated and Single Maturity Date, Fair Value [Abstract]
Available-for-sale investment securities, Fair market Value, Due in one year or less	$ 414,406	$ 243,542
Available-for-sale investment securities, Fair market Value, Due after one year through five years	89,252	58,211
Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Fair Value, Total	503,658	301,753
Available-for-sale investment securities, Amortized Cost, Due in one year or less	414,031	246,276
Available-for-sale investment securities, Amortized Cost, Due after one year through five years	88,650	59,408
Debt Securities, Available-for-sale, Maturity, Allocated and Single Maturity Date, Amortized Cost, Total	$ 502,681	$ 305,684

Balance Sheet Details - Components of Prepaid Expenses and Other Current Assets (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Prepaid clinical trial costs	$ 2,574	$ 2,567
Prepaid research and development costs	1,238	2,293
Australian tax incentive receivable	747	937
Prepaid insurance	857	939
Interest receivable	3,051	1,353
Due from Radionetics ("Note 9")	90	135
Landlord improvements receivable	5,210	605
Receivable for common stock issued	253	0
Other	1,578	1,930
Total	$ 15,598	$ 10,759

Income Taxes (Tables)

12 Months Ended

Dec. 31, 2023

Income Tax Disclosure [Abstract]

Schedule of Deferred Tax Assets and Liabilities

Deferred tax assets and liabilities

Net deferred tax assets are comprised of the following as of December 31, 2023 and 2022 (in thousands):


	December 31,
	2023			2022
Deferred tax assets:
Net operating loss carryforwards	$	81,828		$	69,044
Capitalized research expenses		43,509			22,123
R&D and other tax credits		37,663			22,210
Stock-based compensation		12,207			8,168
Lease liabilities		10,889			648
Accrued expenses and other, net		5,350			4,208
Equity method investment		3,230			—
Total deferred tax assets		194,676			126,401
Deferred tax liabilities:
Right-of use assets		(9,799	)		(313	)
Equity method investment		—			(140	)
Net of deferred tax liabilities		(9,799	)		(453	)
Less: valuation allowance		(184,877	)		(125,948	)
Net deferred tax assets	$	—		$	—

Schedule of Domestic and Foreign Pre-Tax Loss

Income tax benefit

For the three years in the period ended December 31, 2023, domestic and foreign pre-tax loss were (in thousands):


	Year ended December 31,
	2023			2022			2021
Loss before income taxes - Domestic	$	(214,027	)	$	(163,175	)	$	(107,723	)
Income (loss) before income taxes - Foreign		(502	)		(743	)		82
Loss before income taxes - Consolidated	$	(214,529	)	$	(163,918	)	$	(107,641	)

Schedule of Reconciliation of Income Tax Expense

A reconciliation of income tax expense to the amount computed by applying the statutory federal income tax rate to the loss from operations for the three years in the period ended December 31, 2023 is as follows (in thousands):


	Year ended December 31,
	2023			2022			2021
Expected income tax benefit at federal statutory rate	$	(45,051	)	$	(34,423	)	$	(22,605	)
State income tax benefit, net of federal benefit		(797	)		(128	)		(7,083	)
Tax effect of
Change in valuation allowance		59,951			39,733			34,495
R&D credit		(18,179	)		(10,918	)		(7,117	)
Stock-based compensation		1,241			781			1,196
Australian tax incentive		35			266			27
State rate change		44			3,243			(8	)
Uncertain tax positions		2,691			—			—
Other		65			1,446			1,095
Provision for income taxes	$	—		$	—		$	—

Schedule of Unrecognized Tax Benefits

Changes to the Company’s unrecognized tax benefits are summarized in the following table (in thousands):


	Year ended December 31,
	2023		2022		2021
Beginning balance	$	4,110	$	1,553	$	1,092
Increase (decrease) for prior year tax positions		188		837		(34	)
Increase (decrease) for current year tax positions		2,648		1,720		495
Ending balance	$	6,946	$	4,110	$	1,553

Balance Sheet Details - Schedule of Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Accounts Payable and Accrued Liabilities, Current [Abstract]
Accounts payable	$ 6,548	$ 6,883
Accrued clinical trial costs	5,527	1,921
Accrued research and development costs	2,312	4,043
Accrued outside services and professional fees	1,726	1,810
Accrued landlord improvements	3,816	359
Other accrued expenses	3,267	335
Total	$ 23,196	$ 15,351

Equity Incentive Plans - Weighted Average Assumptions Used to Estimate Fair Value of Stock Options Granted to Employees (Details)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Stock Options
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected option term	6 years	6 years 1 month 6 days	6 years
Expected volatility	66.00%	88.00%	86.00%
Risk free interest rate	4.10%	2.80%	1.00%
Expected dividend yield	0.00%	0.00%	0.00%
ESPP
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Expected option term	1 year 1 month 6 days	1 year 3 months 18 days	1 year 7 months 6 days
Expected volatility	66.00%	87.00%	91.00%
Risk free interest rate	5.00%	4.10%	0.30%
Expected dividend yield	0.00%	0.00%	0.00%

- Definition

Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

+ References

+ Details

Commitments and Contingencies

12 Months Ended

Dec. 31, 2023

Commitments and Contingencies Disclosure [Abstract]

Commitments and Contingencies

7. COMMITMENTS AND CONTINGENCIES

Litigation

From time to time, the Company may be subject to various claims and suits arising in the ordinary course of business. The Company does not expect that the resolution of these matters will have a material adverse effect on its financial position or results of operations.

Investment In Radionetics (Tables)

12 Months Ended

Dec. 31, 2023

Schedule of Investments [Abstract]

Summary of primary inputs used in valuing the Radionetics common stock and the Radionetics Warrant

The primary inputs used in valuing the Radionetics common stock and the Radionetics Warrant, were as follows:


Derivative Asset	December 31, 2022			October 15, 2021 and December 31, 2021
Expected term	1.8 years			3.0 years
Expected volatility		116.6	%		111.4	%
Risk free interest rate		4.5	%		0.7	%
Marketability discount		51.0	%		30.0	%

Stockholder's Equity - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands								12 Months Ended
	Feb. 27, 2024	Sep. 15, 2023	Apr. 18, 2022	Oct. 21, 2021	Jul. 28, 2021	Apr. 12, 2021	Aug. 13, 2019	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021	Oct. 31, 2021
Subsidiary Sale Of Stock [Line Items]
Common stock, shares authorized								200,000,000	200,000,000
Common stock and paid-in capital, par value	$ 42							$ 0.001	$ 0.001
Preferred stock, par value								$ 0.001	$ 0.001
Proceeds from issuance of common stock, net	$ 350,000						$ 150,000	$ 369,019	$ 117,242	$ 249,542
Common stock and paid-in capital, shares issued	8,333,334,000							68,175,000	53,877,000
Stock-based compensation expenses								$ 40,937	$ 28,268	$ 17,352
Common Stock
Subsidiary Sale Of Stock [Line Items]
Sale of common stock		11,441,648	5,625,563					12,787,000	5,626,000	14,126,000
Common stock price per share		$ 30.59	$ 22.22
Offering discounts commissions and offering costs net		$ 21,500	$ 7,800
Issuance of common stock, net of transaction costs, shares		11,441,648	5,625,563					12,787,000	5,626,000	14,126,000
Common stock price per share		$ 30.59	$ 22.22
Proceeds from issuance of common stock, net		$ 328,500	$ 117,200
Common stock and paid-in capital, shares issued											50,500,000
Initial Public Offering
Subsidiary Sale Of Stock [Line Items]
Offering discounts commissions and offering costs net						$ 2,400
Proceeds from issuance of common stock, net						$ 72,600
Initial Public Offering \| Common Stock
Subsidiary Sale Of Stock [Line Items]
Sale of common stock				8,712,400		4,562,044
Common stock price per share				$ 19.8		$ 16.44
Offering discounts commissions and offering costs net				$ 10,500
Issuance of common stock, net of transaction costs, shares				8,712,400		4,562,044
Common stock price per share				$ 19.8		$ 16.44
Proceeds from issuance of common stock, net				$ 162,000
ATM Offering
Subsidiary Sale Of Stock [Line Items]
Proceeds from issuance of common stock, net								$ 40,600
Common stock and paid-in capital, shares issued								1,344,865
Private Placement [Member] \| Common Stock
Subsidiary Sale Of Stock [Line Items]
Sale of common stock					851,306
Common stock price per share					$ 17.62
Issuance of common stock, net of transaction costs, shares					851,306
Common stock price per share					$ 17.62
Proceeds from issuance of common stock, net					$ 15,000

Fair Value Measurements

12 Months Ended

Dec. 31, 2023

Fair Value Disclosures [Abstract]

Fair Value Measurements

4. FAIR VALUE MEASUREMENTS

Investment Securities

The Company holds investment securities that consist of highly liquid, investment grade debt securities. The Company determines the fair value of its investment securities based upon valuations reported by its investment accounting and reporting service provider. The investment service provider values the securities using a hierarchical security pricing model that relies primarily on valuations provided by an industry-recognized valuation service. Such valuations may be based on trade prices in active markets for identical assets or liabilities (Level 1 inputs) or valuation models using inputs that are observable either directly or indirectly (Level 2 inputs), such as quoted prices for similar assets or liabilities, yield curves, volatility factors, credit spreads, default rates, loss severity, current market and contractual prices for the underlying instruments or debt, and broker and dealer quotes, as well as other relevant economic measures.

Derivative Asset

On October 15, 2021, the Company received a warrant (the "Radionetics Warrant") to purchase the greater of 3,407,285 additional shares of Radionetics common stock or the number of additional shares of Radionetics common stock that would allow the Company to maintain an aggregate equity interest of 22% of the fully diluted capitalization of Radionetics. The estimated value of the Radionetics Warrant is based on valuations provided by a third-party valuation specialist using unobservable inputs due to little to no market data (Level 3 inputs).

In August 2023, the Company exercised the Radionetics Warrant to purchase 3,407,285 shares of Radionetics common stock with an exercise price of $0.00001 per share, and also cancelled its existing right to maintain an aggregate interest of 22% of the fully diluted capitalization of Radionetics. There were no material changes in the inputs or the total valuation of the Radionetics Warrant in 2023 prior to its exercise and cancellation. Upon exercise, the Radionetics Warrant of $0.7 million was derecognized (see "Note 9").

During the year ended December 31, 2022, the Company recorded $0.6 million of income in the accompanying consolidated statements of operations and comprehensive loss related to the change in value of the Radionetics Warrant.

Financial assets measured at fair value on a recurring basis as of December 31, 2023 and 2022 were as follows (in thousands):


	As of December 31, 2023
	Level 1		Level 2		Level 3		Total
Investment securities:
U.S. government obligations	$	280,209	$	—	$	—	$	280,209
Agency obligations		—		21,270		—		21,270
Certificates of deposit		—		2,440		—		2,440
Corporate debt securities		—		196,755		—		196,755
Commercial paper		—		2,984		—		2,984
Total assets measured at fair value	$	280,209	$	223,449	$	—	$	503,658


	As of December 31, 2022
	Level 1		Level 2		Level 3		Total
Investment securities:
U.S. government obligations	$	93,879	$	—	$	—	$	93,879
Agency obligations		—		58,851		—		58,851
Certificates of deposit		—		4,535		—		4,535
Corporate debt securities		—		142,994		—		142,994
Asset-backed securities		—		1,494		—		1,494
Total Investment securities		93,879		207,874		—		301,753
Derivative Assets:
Radionetics Warrant		—		—		668		668
Total assets measured at fair value	$	93,879	$	207,874	$	668	$	302,421

The Company’s policy is to recognize transfers between levels of the fair value hierarchy on the date of the event or change in circumstances that caused the transfer. There were no transfers into or out of Level 3 during the years ended December 31, 2023 and 2022.

The following is the Level 3 activity for the Company’s derivative asset:


	Year Ended December 31,
	2023			2022
Derivative asset at beginning of period	$	668		$	68
Gain on change in fair value of derivative asset		—			600
Exercise of derivative asset		(668	)		—
Balance at end of period	$	—		$	668

- Definition

The entire disclosure for the fair value of financial instruments (as defined), including financial assets and financial liabilities (collectively, as defined), and the measurements of those instruments as well as disclosures related to the fair value of non-financial assets and liabilities. Such disclosures about the financial instruments, assets, and liabilities would include: (1) the fair value of the required items together with their carrying amounts (as appropriate); (2) for items for which it is not practicable to estimate fair value, disclosure would include: (a) information pertinent to estimating fair value (including, carrying amount, effective interest rate, and maturity, and (b) the reasons why it is not practicable to estimate fair value; (3) significant concentrations of credit risk including: (a) information about the activity, region, or economic characteristics identifying a concentration, (b) the maximum amount of loss the entity is exposed to based on the gross fair value of the related item, (c) policy for requiring collateral or other security and information as to accessing such collateral or security, and (d) the nature and brief description of such collateral or security; (4) quantitative information about market risks and how such risks are managed; (5) for items measured on both a recurring and nonrecurring basis information regarding the inputs used to develop the fair value measurement; and (6) for items presented in the financial statement for which fair value measurement is elected: (a) information necessary to understand the reasons for the election, (b) discussion of the effect of fair value changes on earnings, (c) a description of [similar groups] items for which the election is made and the relation thereof to the balance sheet, the aggregate carrying value of items included in the balance sheet that are not eligible for the election; (7) all other required (as defined) and desired information.

+ References + Details

Summary of Significant Accounting Policies (Policies)

12 Months Ended

Dec. 31, 2023

Accounting Policies [Abstract]

Description of Business

Crinetics Pharmaceuticals, Inc. (the “Company”) is a clinical-stage pharmaceutical company incorporated in Delaware on November 18, 2008 and based in San Diego, California. The Company is focused on the discovery, development and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors. In January 2017, the Company established a wholly-owned Australian subsidiary, Crinetics Australia Pty Ltd (“CAPL”), in order to conduct various preclinical and clinical activities for its development candidates.

Principles of Consolidation and Foreign Currency Transactions

The consolidated financial statements include the accounts of the Company and CAPL. All intercompany accounts and transactions have been eliminated in consolidation. The functional currency of both the Company and CAPL is the U.S. dollar. Assets and liabilities that are not denominated in the functional currency are remeasured into U.S. dollars at foreign currency exchange rates in effect at the balance sheet date except for nonmonetary assets, which are remeasured at historical foreign currency exchange rates in effect at the date of transaction. Net realized and unrealized gains and losses from foreign currency transactions and remeasurement are reported in other income (expense), in the accompanying consolidated statements of operations and comprehensive loss and were not material for all periods presented.

Segment Reporting

Operating segments are identified as components of an enterprise about which discrete financial information is available for evaluation by the chief operating decision-maker ("CODM"), in making decisions regarding resource allocation and assessing performance. The Company views its operations and manages its business in one operating segment.

Liquidity

From inception, the Company has devoted substantially all of its efforts to drug discovery and development and conducting preclinical studies and clinical trials. The Company has a limited operating history and the sales and income potential of the Company’s business and market are unproven. Successful transition to attaining profitable operations is dependent upon achieving a level of revenues adequate to support the Company’s cost structure. The Company has experienced net losses and negative cash flows from operating activities since its inception and has an accumulated deficit of $653.7 million as of December 31, 2023.

As of December 31, 2023, the Company had $558.6 million in unrestricted cash, cash equivalents and investment securities, which the Company believes is sufficient to meet its funding requirements for at least the next 12 months.

The Company expects to continue to incur net losses for the foreseeable future and believes it will need to raise substantial additional capital to accomplish its business plan over the next several years. The Company plans to continue to fund its losses from operations and capital funding needs through a combination of equity offerings, debt financings or other sources, including potential collaborations, licenses and other similar arrangements. If the Company is not able to secure adequate additional funding, the Company may be forced to make reductions in spending, extend payment terms with suppliers, liquidate assets where possible, or suspend or curtail planned programs. Any of these actions could materially harm the Company’s business, results of operations and prospects. There can be no assurance as to the availability or terms upon which such financing and capital might be available in the future.

Use of Estimates

The Company’s consolidated financial statements are prepared in accordance with U.S. generally accepted accounting principles (“U.S. GAAP”). The preparation of the Company’s consolidated financial statements requires it to make estimates and assumptions that impact the reported amounts of assets, liabilities, revenues and expenses and the disclosure of contingent assets and liabilities in the Company’s consolidated financial statements and accompanying notes. The most significant estimates in the Company’s consolidated financial statements relate to accrual of research and development expenses, valuation of stock-based awards, fair values of financial instruments, revenue recognition, and the assumptions underlying the determination of the estimated incremental borrowing rate for the determination of the Company’s operating lease right-of-use assets. Estimates are based on historical experiences or on forecasts, including information received from third parties and various other factors that the Company believes are reasonable under the circumstances. Estimates are

periodically reviewed in light of changes in circumstances, facts and experience. Actual results could differ from those estimates

Investment in Radionetics

In October 2021, the Company, together with other investors, announced the formation of Radionetics Oncology, Inc. ("Radionetics").

The Company first analyzes its investment in another entity to determine if the entity is a variable interest entity (“VIE”) and if so, whether the Company is the primary beneficiary requiring consolidation. An entity is considered a VIE if (1) the entity does not have enough equity to finance its own activities without additional support, (2) the entity’s at-risk equity holders lack the characteristics of a controlling financial interest, or (3) the entity is structured with non-substantive voting rights. VIEs are consolidated by the primary beneficiary, which is the entity that has both the power to direct the activities that most significantly impact the VIE’s economic performance and the obligation to absorb losses or the right to receive benefits from the VIE that potentially could be significant to the VIE. Variable interests in a VIE can be contractual, ownership, or other financial interests. The Company re-assesses its investment upon reconsideration events to determine whether the Company is the primary beneficiary of the VIE, in which case the Company would consolidate the VIE.

If it has been determined that the Company is not the primary beneficiary but does have the ability to exercise significant influence over the VIE, the Company accounts for the unconsolidated investment under the equity method of accounting.

Fair Value Measurements

The accounting guidance defines fair value, establishes a consistent framework for measuring fair value and expands disclosure for each major asset and liability category measured at fair value on either a recurring or non-recurring basis. Fair value is defined as an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. As a basis for considering such assumptions, the accounting guidance establishes a three-tier fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows:

Level 1: Observable inputs such as quoted prices in active markets.

Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly.

Level 3: Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions about risk and the assumptions market participants would use in pricing the asset or liability developed based on the best information available in the circumstances.

The carrying amounts of the Company’s current financial assets, restricted cash and current financial liabilities are considered to be representative of their respective fair values because of the short-term nature of those instruments. The Company recorded the derivative asset (see "Note 9") and investment securities (see "Note 4") at fair value.

Cash, Cash Equivalents and Restricted Cash

Cash and cash equivalents include cash held in readily available checking and money market accounts, as well as short-term debt securities with maturities of three months or less when purchased. Restricted cash represents cash held as collateral for the Company’s facility leases and is reported as a long-term asset in the accompanying consolidated balance sheets. Cash and cash equivalents are considered Level 1 investments.

Investment Securities

Our investment in debt securities have been classified as “available-for-sale” and are carried at fair value as determined based upon quoted market prices or pricing models for similar securities at period end. Investments with contractual maturities less than 12 months at the balance sheet date are considered short-term investments. Investments with contractual maturities beyond one year are also classified as short-term due to the Company’s ability to liquidate the investment for use in operations within the next 12 months.

The Company elected the practical expedient to exclude the applicable accrued interest from both the fair value and amortized costs basis of available-for-sale securities for purposes of identifying and measuring an impairment. Accrued interest receivable on available-for-sale securities is recorded in prepaid expenses and other current assets in the accompanying consolidated balance sheets. The Company’s accounting policy is to not measure an allowance for credit loss for accrued interest receivable and to write-off any uncollectible accrued interest receivable as a reversal of interest income in a timely manner, which the Company considers to be in the period in which the Company determines the accrued interest will not be collected.

Realized gains and losses on investment securities are derived using the specific identification method for determining the cost of securities sold and are included in other income (expenses), net in the accompanying consolidated statements of operations and comprehensive loss. The Company has not realized any significant gains or losses on sales of available-for-sale debt securities during any of the periods presented. Interest income is recognized when earned and is included in interest income in the accompanying consolidated statements of operations and comprehensive loss, as are the amortization of purchase premiums and accretion of purchase discounts on investment securities.

Effective January 1, 2023, at each balance sheet date, the Company assesses available-for-sale debt securities in an unrealized loss position to determine whether the unrealized loss or any potential credit losses should be recognized in net loss. For available-for-sale debt securities in an unrealized loss position, the Company first assesses whether it intends to sell, or it is more likely than not that it will be required to sell, the security before recovery of its amortized cost basis. If either of the criteria regarding intent or requirement to sell is met, the security’s amortized cost basis is written down to fair value through net loss. For available-for-sale securities that do not meet the criteria, the Company evaluates whether the decline in fair value has resulted from credit losses or other factors. In making this assessment, the Company considers the severity of the impairment, any changes in interest rates, underlying credit ratings, and forecasted recovery, among other factors. The credit-related portion of unrealized losses, and any subsequent improvements, are recorded as an allowance in interest income. There have been no impairment or credit losses recognized during the periods presented in the accompanying consolidated statements of operations and comprehensive loss. Unrealized gains and losses that are not credit-related are included in accumulated other comprehensive loss in the accompanying consolidated balance sheets.

Concentrations of Credit Risk

Financial instruments that potentially subject the Company to significant concentrations of credit risk consist primarily of cash, cash equivalents and investment securities. The Company maintains deposits in federally insured financial institutions in excess of federally insured limits. The Company has not experienced any losses in such accounts and believes it is not exposed to significant risk on its cash balances due to the financial position of the depository institution in which those deposits are held. Additionally, the Company has established guidelines regarding approved investments and maturities of investments, which are designed to maintain safety and liquidity.

Leases

The Company determines if an arrangement is a lease at the inception of the arrangement. Short-term leases with an initial term of 12 months or less are not recorded on the balance sheets. Leases with a term longer than 12 months that are determined to be operating leases are included in operating lease right-of-use assets, operating lease liabilities and noncurrent operating lease liabilities in the consolidated balance sheets at the accounting commencement date of the arrangement. The Company accounts for each separate lease and non-lease component as a single lease component. When the Company’s leases do not provide an implicit rate, an incremental borrowing rate is used based on the information available at accounting commencement dates in determining the present value of lease payments. The incremental borrowing rate is the rate of interest that the Company would expect to pay to borrow over a similar term, and on a collateralized basis, an amount equal to the lease payments in a similar economic environment. The Company’s lease terms may include options to extend or terminate the lease when the Company is reasonably certain that it will exercise such options. Lease expense for lease payments is recognized on a straight-line basis over the lease term. Lease agreements may contain variable costs such as common area maintenance, insurance, taxes or other costs. Such variable lease costs are expensed as incurred. The Company assesses its leases to determine whether the arrangements contain lease incentives.

If a lease is modified, the modified contract is evaluated to determine whether it is or contains a lease. If a lease continues to exist, the lease modification is determined to be a separate contract when the modification grants the lessee an additional right-of-use asset that is not included in the original lease and the lease payments increase commensurate with the standalone price for the additional right-of-use asset. A lease modification that results in a separate contract will be accounted for in the same manner as a new lease. For a modification that is not a separate contract, the Company will reassess the lease classification and incremental borrowing rate using the modified terms and conditions and the facts and circumstances as of the effective date of the modification and recognize the amount of the remeasurement of the lease liability for the modified lease as an adjustment to the corresponding operating lease right-of-use asset.

Property and Equipment, Net

Property and equipment consist of leasehold improvements, and lab and various other equipment. Such assets are stated at cost and depreciated on a straight-line basis over the estimated useful life of the related assets. The Company estimates its useful lives of its lab and other equipment as follows: lab equipment – three to five years; office equipment - three to five years; computer and software – three years. Leasehold improvements are amortized over the shorter of the estimated useful life of the improvement or the remaining term of the associated lease.

Repairs and maintenance costs are charged to expense as incurred and expenditures that materially extend the useful lives of assets are capitalized.

Impairment of Long-Lived Assets

The Company reviews long-lived assets for impairment whenever events or changes in business circumstances indicate that the carrying amount of the assets (or asset group) may not be fully recoverable.

Factors considered in deciding when to perform an impairment review include significant underperformance of the business in relation to expectations, significant negative industry or economic trends, and significant changes or planned changes in the use of the assets. An impairment loss is recognized when estimated undiscounted future cash flows expected to result from the use of an asset (or asset group) are less than its carrying amount. If such assets are considered impaired, the impairment loss recognized is measured as the excess of the carrying value of the impaired asset over its fair value, determined based on future cash flows or appraised values, depending on the nature of the asset (or asset group). The Company has not recognized any impairment losses in any of the periods presented in these consolidated financial statements.

Revenue Recognition

The Company has generated revenue from licensing arrangements and supply agreements. The Company recognizes revenues when, or as, the promised goods or services are transferred to customers in an amount that reflects the consideration to which it expects to be entitled in exchange for those services. To determine revenue recognition for arrangements, the Company performs the following five steps: (1) identify the contract(s) with a customer; (2) identify the performance obligation(s) in the contract; (3) determine the transaction price; (4) allocate the transaction price to the performance obligation(s) in the contract; and (5) recognize revenue when (or as) the performance obligation(s) are satisfied. At contract inception, the Company assesses the goods or services promised within each contract, assesses whether each promised good or service is distinct and identifies those that are performance obligations. The Company recognizes as revenue the amount of the transaction price that is allocated to the respective performance obligation when, or as, the performance obligation is satisfied.

The Company has entered into licensing and collaboration agreements that mainly include the following: (i) upfront considerations; (ii) payments associated with achieving certain milestones; and (iii) royalties based on specified percentages of net product sales, if any.

The Company has also entered into a manufacturing and supply arrangement that includes reimbursements of costs plus a pre-determined margin.

At the inception of a collaboration arrangement, the Company first assesses whether the contractual arrangement is within the scope of The Accounting Standards Codification ("ASC") Topic 808, Collaborative Arrangements (“ASC 808”) to determine whether the arrangement involves a joint operating activity and involves two (or more) parties that are both active participants in the activity and exposed to significant risks and rewards dependent on the commercial success of such activity. Then the Company determines whether the collaboration arrangement in its entirety represents a contract with a customer as defined by ASC Topic 606, Revenue From Contracts with Customers ("ASC 606"). If only a portion of the collaboration arrangement is potentially with a customer, the Company applies the distinct good or service unit-of-account guidance in ASC 606 to determine whether there is a unit of account that.

At the initiation of an agreement, the Company analyzes each unit of account within the contract to determine if the counterparty is a customer in the context of the unit of account.

The Company considers a variety of factors in determining the appropriate estimates and assumptions under the arrangements, such as whether the elements are distinct performance obligations, whether there are observable standalone prices, whether the license is functional or symbolic, and whether the Company is acting as the agent or principal. The Company evaluates each performance obligation to determine if it can be satisfied and recognized as revenue at a point in time or over time.

At the inception of arrangements that include milestone payments, the Company uses judgment to estimate the amount of milestone payments, which is a variable consideration, to include in the transaction price using the most likely method. If it is probable that a significant revenue reversal will not occur, then the estimated amount is included in the transaction price. Milestone payments that are not within the Company's or the licensee’s control, such as regulatory approvals, are not included in the transaction price until those approvals are received. At the end of each reporting period, the Company re-evaluates the estimated variable consideration included in the transaction price and any related constraint and, as necessary, adjusts the estimate of the overall transaction price. Any adjustments will be recorded on a cumulative catch-up basis, which would affect revenues and earnings in the period of adjustment.

The Company develops estimates of the standalone selling price for each distinct performance obligation. Variable consideration that relates specifically to efforts to satisfy specific performance obligations is allocated entirely to those performance obligations. Other components of the transaction price are allocated based on the relative standalone selling price, over which management has applied significant judgment. The Company determines the standalone selling price for license-related performance obligations using a market approach, which may include assumptions such as forecasted revenues, development timelines, discount rates and probabilities of success. The Company estimates the standalone selling price for the data exchange performance obligation (see "Note 8") by forecasting the expected costs of satisfying a performance obligation plus a predetermined margin.

In the case of a license that is a distinct performance obligation, the Company recognizes revenue allocated to the license from non-refundable, up-front fees at the point in time when the license is transferred to the licensee and the licensee can use and benefit from the license. For licenses that are bundled with other distinct or combined obligations, the Company uses judgment to assess the nature of the performance obligation to determine whether the performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue. If the performance obligation is satisfied over time, then the Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of performance and related revenue recognition.

The selection of the method to measure progress towards completion requires judgment and is based on the nature of the products or services to be provided. The Company has used the cost-to-cost measure of progress because it best depicts the transfer of control to the customer which occurs as the Company incurs costs. Under the cost-to-cost measure of progress, the extent of progress towards completion is measured based on the ratio of costs incurred to date to the total estimated costs at completion of the performance obligation, which is considered an input method. The Company uses judgment to estimate the total cost of these performance obligations, which include subcontractors' costs, labor, materials, other direct costs and an allocation of indirect costs. The Company evaluates these cost estimates and the progress each reporting period and, as necessary, the Company adjusts the measure of progress and related revenue recognition.

Sales-based milestones and royalties are recognized at the later of when the subsequent sale or usage occurs or the performance obligation for which some or all of the sales-based milestones and royalties have been allocated to has been satisfied or partially satisfied.

Research and Development Expense

Research and Development Expenses

Research and development (“R&D”) expenses consist primarily of salaries, payroll taxes, employee benefits and stock-based compensation for individuals involved in R&D efforts, as well as consulting expenses, third-party R&D expenses, laboratory supplies, clinical materials and overhead, including facilities and depreciation costs, offset by the Australian Tax Incentive discussed below. R&D expenses are charged to expense as incurred. Payments made prior to the receipt of goods or services to be used in R&D are capitalized until the goods or services are received and are recorded as prepaid expenses and other current assets.

Costs incurred under contracts with contract research organizations ("CROs") that conduct and manage the Company’s clinical trials are also included in R&D expenses. The financial terms and activities of these agreements vary from contract to contract and may result in uneven expense levels. Clinical trial activities are accrued and expensed based on estimates of the period in which services and efforts provided by CROs and other third parties. Estimates are determined by reviewing cost information provided by CROs, other third-party vendors and internal clinical personnel, and contractual arrangements with CROs and the scope of work to be performed. If the amounts that the Company is obligated to pay under its clinical trial agreements are modified (for instance, because of changes in the clinical trial protocol or scope of work to be performed), the Company adjusts its accruals accordingly on a prospective basis. Revisions to contractual payment obligations are charged to expense in the period in which the facts that give rise to the revision become reasonably certain.

Australian Tax Incentive

CAPL is eligible to obtain a cash refund from the Australian Taxation Office for eligible R&D expenditures under the Australian R&D Tax Incentive Program (the “Australian Tax Incentive”). The Australian Tax Incentive is recognized as a reduction to R&D expense when there is reasonable assurance that the relevant expenditure has been incurred, the amount can be reliably measured and that the Australian Tax Incentive will be received. The Australian Taxation Office has a recapture right for a period of four years.

The Company recognized reductions to R&D expense of $43,000, $0.8 million and $0.3 million for the years ended December 31, 2023, 2022 and 2021, respectively.

Patent Costs

All costs incurred for the filing of patent applications are recorded as general and administrative expenses in the accompanying consolidated statements of operations and comprehensive loss when incurred, as the recoverability of these expenses is uncertain.

Stock-Based Compensation

Stock-based compensation expense represents the estimated grant date fair value of the Company’s equity awards, consisting of stock options, restricted stock units and shares issued under the Company’s Employee Stock Purchase Plan, recognized over the requisite service period of such awards (usually the vesting period) on a straight-line basis. The Company estimates the fair value of all stock option grants using the Black-Scholes option pricing model and recognizes forfeitures as they occur. Restricted stock units are valued using the grant date stock price. For stock awards for which vesting is subject to performance-based milestones, the expense is recorded over the remaining service period after the point when the achievement of the milestone is probable, or the performance condition has been achieved.

Income Taxes

The Company accounts for income taxes under the asset and liability method, which requires the recognition of deferred tax assets and liabilities for the expected future tax consequences of events that have been included in the consolidated financial statements. Under this method, deferred tax assets and liabilities are determined based on the differences between the consolidated financial statements and tax basis of assets and liabilities using enacted tax rates in effect for the year in which the differences are expected to reverse. The effect of a change in tax rates on deferred tax assets and liabilities is recognized in income in the period that includes the enactment date.

The Company recognizes net deferred tax assets to the extent that the Company believes these assets are more likely than not to be realized. In making such a determination, management considers all available positive and negative evidence, including future reversals of existing taxable temporary differences, projected future taxable income, tax-planning strategies, and results of recent operations. If management determines that the Company would be able to realize its deferred tax assets in the future in excess of their net recorded amount, management would make an adjustment to the deferred tax asset valuation allowance, which would reduce the provision for income taxes.

The Company records uncertain tax positions on the basis of a two-step process whereby (1) management determines whether it is more likely than not that the tax positions will be sustained on the basis of the technical merits of the position and (2) for those tax positions that meet the more-likely-than-not recognition threshold, management recognizes the largest amount of tax benefit that is more than 50% likely to be realized upon ultimate settlement with the related tax authority. The Company recognizes interest and penalties related to unrecognized tax benefits within income tax expense, and any accrued interest and penalties would be included within the related tax liability. No such costs were recorded during the three years ended December 31, 2023.

Comprehensive Loss

Comprehensive loss is comprised of the Company’s net loss and the unrealized gains or losses on the Company’s available for sale investment securities for all periods presented. The cumulative amount of unrealized gains and losses is reflected as a separate component of stockholders' equity in the accompanying consolidated balance sheets as accumulated other comprehensive income (loss). There were no tax effects for the years ended December 31, 2023, 2022 and 2021.

Net Loss Per Share

Basic net loss per share is computed by dividing the net loss by the weighted-average number of common shares outstanding for the period, without consideration for potentially dilutive securities. Diluted net loss per share is computed by dividing the net loss by the weighted-average number of shares of common stock and dilutive common stock equivalents outstanding for the period determined using the treasury-stock and if-converted methods. Dilutive common stock equivalents are comprised of common stock subject to repurchase and stock options outstanding under the Company’s stock option plan. For all periods

presented, there is no difference in the number of shares used to calculate basic and diluted shares outstanding as inclusion of the potentially dilutive securities on loss per share would be antidilutive.


	Year ended December 31,
	2023		2022		2021
Stock options		12,627		9,757		6,554
Restricted stock units		814		290		—
Employee stock purchase plan		302		282		207
Unvested common stock subject to repurchase		—		—		1
Total		13,743		10,329		6,762

Recent Accounting Pronouncements

Recently Adopted Accounting Pronouncements

ASU 2016-13

In June 2016, the Financial Accounting Standards Board (“FASB”) issued Accounting Standards Update ("ASU") 2016-13, “Financial Instruments - Credit Losses (Topic 326): Measurement of Credit Losses on Financial Instruments” (“Topic 326”). Topic 326 amends guidance on reporting credit losses for assets held at amortized cost basis and available for sale debt securities. For assets held at amortized cost basis, Topic 326 eliminates the probable initial recognition threshold in current GAAP and, instead, requires an entity to reflect its current estimate of all expected credit losses. The allowance for credit losses is a valuation account that is deducted from the amortized cost basis of the financial assets to present the net amount expected to be collected. For available for sale debt securities, credit losses should be measured in a manner like current GAAP, however Topic 326 will require that credit losses be presented as an allowance rather than as a write-down. This ASU update affects entities holding financial assets and net investment in leases that are not accounted for at fair value through net income (loss). The Company adopted ASU 2016-13 as of January 1, 2023, which did not have a material impact on its consolidated financial statements.

Recent Accounting Pronouncements

ASU 2023-07

In November 2023, the FASB issued ASU 2023-07, Segment Reporting (Topic 280) Improvements to Reportable Segment Disclosures (“Topic 280”), which modifies the disclosure and presentation requirements of reportable segments. The amendments in the update require the disclosure of significant segment expenses that are regularly provided to the CODM and included within each reported measure of segment profit and loss. The amendments also require disclosure of all other segment items by reportable segment and a description of its composition. Additionally, the amendments require disclosure of the title and position of the CODM and an explanation of how the CODM uses the reported measure(s) of segment profit or loss in assessing segment performance and deciding how to allocate resources. Lastly, the amendment requires that a public entity that has a single reportable segment provide all the disclosures required by ASU 2023-07 and all existing segment disclosures in Topic 280. This update is effective for annual periods beginning after December 15, 2023, and interim periods within fiscal years beginning after December 15, 2024. Early adoption is permitted. The Company is currently evaluating the impact that this guidance will have on the presentation of its consolidated financial statements and accompanying notes.

ASU 2023-09

In December 2023, the FASB issued ASU No. 2023-09, “Income Taxes (Topic 740): Improvements to Income Tax Disclosures”. ASU 2023-09 requires disaggregated information about a reporting entity’s effective tax rate reconciliation as well as information on income taxes paid. ASU 2023-09 is effective for public entities with annual periods beginning after December 15, 2024, with early adoption permitted. The Company is currently evaluating the impact of this guidance on its consolidated financial statements.

Equity Incentive Plans - Summary of Activity Under Stock Option Plans (Details) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2023 USD ($) $ / shares shares
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Options Outstanding, Beginning balance \| shares	9,757,329
Options Outstanding, Granted \| shares	4,824,597
Options Outstanding, Exercised \| shares	(1,282,603)
Options Outstanding, Forfeited and expired \| shares	(672,199)
Options Outstanding, Ending balance \| shares	12,627,124
Options Outstanding,Vested and expected to vest \| shares	12,627,124
Options Exercisable, Ending balance \| shares	5,255,484
Weighted-Average Exercise Price, Beginning balance \| $ / shares	$ 17.79
Weighted-Average Exercise Price, Granted \| $ / shares	20.67
Weighted Average Exercise Price, Vested \| $ / shares	15.66
Weighted Average Exercise Price, Forfeited and expired \| $ / shares	20.56
Weighted-Average Exercise Price, Ending balance \| $ / shares	18.96
Weighted-Average Exercise Price, Vested and expected to vest \| $ / shares	18.96
Weighted-Average Exercise Price, Exercisable \| $ / shares	$ 17.36
Weighted-Average Remaining Term, Ending balance	8 years
Weighted-Average Remaining Term, Vested and expected to vest	8 years
Weighted-Average Remaining Term, Exercisable	6 years 8 months 12 days
Aggregate Intrinsic Value, Ending balance \| $	$ 209,884
Aggregate Intrinsic Value, Vested and expected to vest \| $	209,884
Aggregate Intrinsic Value, Exercisable \| $	$ 95,731
Restricted Stock Units
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Options Outstanding, Beginning balance \| shares	290,311
Options Outstanding, Granted \| shares	666,621
Options Outstanding, Vested \| shares	(81,294)
Options Outstanding, Forfeited and expired \| shares	(62,004)
Options Outstanding, Ending balance \| shares	813,634
Weighted-Average Exercise Price, Beginning balance \| $ / shares	$ 19.88
Weighted-Average Exercise Price, Granted \| $ / shares	19.62
Weighted Average Exercise Price, Vested \| $ / shares	19.54
Weighted Average Exercise Price, Forfeited and expired \| $ / shares	19.77
Weighted-Average Exercise Price, Ending balance \| $ / shares	$ 19.71

Summary of Significant Accounting Policies - Schedule of Potentially Dilutive Securities not Included in Calculation of Diluted Net Loss Per Share (Details) - shares shares in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potentially dilutive securities excluded from calculation of diluted net loss per share	13,743	10,329	6,762
Employee Stock Purchase Plan
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potentially dilutive securities excluded from calculation of diluted net loss per share	302	282	207
Restricted Stock Units
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potentially dilutive securities excluded from calculation of diluted net loss per share	814	290	0
Stock Options
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potentially dilutive securities excluded from calculation of diluted net loss per share	12,627	9,757	6,554
Unvested Common Stock Subject To Repurchase
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Potentially dilutive securities excluded from calculation of diluted net loss per share	0	0	1

Fair Value Measurements - Additional Information (Details) - USD ($)		1 Months Ended	12 Months Ended
	Oct. 15, 2021	Aug. 31, 2023	Dec. 31, 2023	Dec. 31, 2022
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Fair value assets transferred into level 3			$ 0
Fair value assets transferred into level 3				$ 0
Change in valuation of derivative asset				$ 600,000
Radionetics Warrant
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]
Equity interest percentage	22.00%	22.00%
Fair Value Adjustment of Warrants		$ 700,000
Additional common shares issued	3,407,285	3,407,285

Investment Securities - Summary of Available-For-Sale Investment Securities Held by the Company (Details) - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Schedule Of Available For Sale Securities [Line Items]
Available-for-sale investment securities, Amortized Cost	$ 502,681	$ 305,684
Available-for-sale investment securities, Gross Unrealized Gains	1,275	12
Available-for-sale investment securities, Gross Unrealized Losses	(298)	(3,943)
Available-for-sale investment securities, Fair Market Value	503,658	301,753
Agency Obligations
Schedule Of Available For Sale Securities [Line Items]
Available-for-sale investment securities, Amortized Cost	21,271	59,280
Available-for-sale investment securities, Gross Unrealized Gains	16	11
Available-for-sale investment securities, Gross Unrealized Losses	(17)	(440)
Available-for-sale investment securities, Fair Market Value	21,270	58,851
U.S. Government Obligations
Schedule Of Available For Sale Securities [Line Items]
Available-for-sale investment securities, Amortized Cost	279,577	94,948
Available-for-sale investment securities, Gross Unrealized Gains	731	1
Available-for-sale investment securities, Gross Unrealized Losses	(99)	(1,070)
Available-for-sale investment securities, Fair Market Value	280,209	93,879
Certificates of Deposit
Schedule Of Available For Sale Securities [Line Items]
Available-for-sale investment securities, Amortized Cost	2,450	4,629
Available-for-sale investment securities, Gross Unrealized Gains	2	0
Available-for-sale investment securities, Gross Unrealized Losses	(12)	(94)
Available-for-sale investment securities, Fair Market Value	2,440	4,535
Commercial Paper
Schedule Of Available For Sale Securities [Line Items]
Available-for-sale investment securities, Amortized Cost	2,984
Available-for-sale investment securities, Gross Unrealized Gains	0
Available-for-sale investment securities, Gross Unrealized Losses	0
Available-for-sale investment securities, Fair Market Value	2,984
Corporate Debt Securities
Schedule Of Available For Sale Securities [Line Items]
Available-for-sale investment securities, Amortized Cost	196,399	145,330
Available-for-sale investment securities, Gross Unrealized Gains	526	0
Available-for-sale investment securities, Gross Unrealized Losses	(170)	(2,336)
Available-for-sale investment securities, Fair Market Value	$ 196,755	142,994
Asset-Backed Securities
Schedule Of Available For Sale Securities [Line Items]
Available-for-sale investment securities, Amortized Cost		1,497
Available-for-sale investment securities, Gross Unrealized Gains		0
Available-for-sale investment securities, Gross Unrealized Losses		(3)
Available-for-sale investment securities, Fair Market Value		$ 1,494

Income Taxes - Schedule of Unrecognized Tax Benefits (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
Beginning balance	$ 4,110	$ 1,553	$ 1,092
Increase (decrease) for prior year tax positions	188	837	(34)
Increase (decrease) for current year tax positions	2,648	1,720	495
Ending balance	$ 6,946	$ 4,110	$ 1,553

Summary of Significant Accounting Policies

12 Months Ended

Dec. 31, 2023

Accounting Policies [Abstract]

Summary of Significant Accounting Policies

2. SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

Use of Estimates

periodically reviewed in light of changes in circumstances, facts and experience. Actual results could differ from those estimates.

Investment in Radionetics

In October 2021, the Company, together with other investors, announced the formation of Radionetics Oncology, Inc. ("Radionetics").

Fair Value Measurements

Level 1: Observable inputs such as quoted prices in active markets.

Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly.

Cash, Cash Equivalents and Restricted Cash

Investment Securities

Concentrations of Credit Risk

Leases

Property and Equipment, Net

Repairs and maintenance costs are charged to expense as incurred and expenditures that materially extend the useful lives of assets are capitalized.

Impairment of Long-Lived Assets

Revenue Recognition

The Company has also entered into a manufacturing and supply arrangement that includes reimbursements of costs plus a pre-determined margin.

At the initiation of an agreement, the Company analyzes each unit of account within the contract to determine if the counterparty is a customer in the context of the unit of account.

Research and Development Expenses

Australian Tax Incentive

The Company recognized reductions to R&D expense of $43,000, $0.8 million and $0.3 million for the years ended December 31, 2023, 2022 and 2021, respectively.

Patent Costs

Stock-Based Compensation

Income Taxes

Comprehensive Loss

Net Loss Per Share


	Year ended December 31,
	2023		2022		2021
Stock options		12,627		9,757		6,554
Restricted stock units		814		290		—
Employee stock purchase plan		302		282		207
Unvested common stock subject to repurchase		—		—		1
Total		13,743		10,329		6,762

Recently Adopted Accounting Pronouncements

ASU 2016-13

Recent Accounting Pronouncements

ASU 2023-07

ASU 2023-09

Stockholder's Equity

12 Months Ended

Dec. 31, 2023

Stockholders' Equity Note [Abstract]

Stockholders' Equity

10. STOCKHOLDERS’ EQUITY

Stock Offerings

On April 12, 2021, the Company completed an underwritten public offering of 4,562,044 shares of its common stock at a price to the public of $16.44 per share. Proceeds from the offering were approximately $72.6 million, net of underwriting discounts and commissions and offering costs of $2.4 million.

On July 28, 2021, the Company entered into a stock purchase agreement for the private placement of 851,306 shares of its common stock at a price of $17.62 per share (the “Private Placement”), which shares were issued on July 30, 2021. Proceeds from the offering were approximately $15.0 million.

On October 21, 2021, the Company completed an underwritten public offering of 8,712,400 shares of its common stock at a price to the public of $19.80 per share. Proceeds from the offering were approximately $162.0 million, net of underwriting discounts and commissions and offering costs of $10.5 million.

On April 18, 2022, the Company completed an underwritten public offering of 5,625,563 shares of its common stock at a price to the public of $22.22 per share. Net proceeds from the offering were approximately $117.2 million, after underwriting discounts and commissions and estimated offering costs of approximately $7.8 million.

On September 15, 2023, the Company completed an underwritten public offering of 11,441,648 shares of its common stock at a price to the public of $30.59 per share. Net proceeds from the offering were approximately $328.5 million, after underwriting discounts and commissions and offering costs of approximately $21.5 million.

Shelf Registration Statements and ATM Offering

On August 13, 2019, the Company entered into a Sales Agreement, as amended on August 12, 2022 (as amended, the “Sales Agreement”) with SVB Leerink LLC and Cantor Fitzgerald & Co. (collectively, the “Sales Agents”), under which the Company may, from time to time, sell up to $150 million of shares of its common stock through the Sales Agents (the “ATM Offering”).

During the year ended December 31, 2023, the Company issued 1,344,865 shares of common stock in the ATM Offering for net proceeds of approximately $40.6 million, after deducting commissions.

- Definition

The entire disclosure for equity.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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Reference 2: http://www.xbrl.org/2003/role/disclosureRef
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Reference 6: http://www.xbrl.org/2003/role/disclosureRef
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Reference 8: http://www.xbrl.org/2003/role/disclosureRef
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Reference 9: http://www.xbrl.org/2003/role/disclosureRef
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Reference 10: http://fasb.org/us-gaap/role/ref/legacyRef
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-Subparagraph (d)
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-URI https://asc.fasb.org//1943274/2147481112/505-10-50-18

+ Details

Income Taxes

12 Months Ended

Dec. 31, 2023

Income Tax Disclosure [Abstract]

Income Taxes

12. INCOME TAXES

The Company is subject to taxation in the United States, various state jurisdictions and Australia; however, as it has operated at a loss since inception, it has not paid income taxes in any of the jurisdictions in which it has operated. At December 31, 2023, the Company had federal, state, and foreign net operating loss (“NOL”) carryforwards of approximately $311.3 million, $228.6 million and $1.7 million, respectively. The federal loss carryforwards generated after 2017 of $305.0 million will carryforward indefinitely and can be used to offset up to 80% of future annual taxable income, while those loss carryforwards generated prior to 2018 begin expiring in 2035, unless previously utilized. $0.8 million of the state loss carryforwards will carryforward indefinitely. The other state loss carryforwards begin expiring in 2035, unless previously utilized. The Company's foreign loss carryforwards do not expire. The Company also has federal and California R&D credit carryforwards and federal Orphan Drug Credits totaling $16.3 million, $9.5 million, and $20.5 million, respectively. The federal R&D credits begin to expire in 2030, unless previously utilized, while the state credits do not expire. The federal Orphan Drug credit carryforwards will begin to expire in 2040, unless previously utilized.

The Company’s NOL and credit carryforwards to offset future taxable income may be subject to a substantial annual limitation upon future utilization as a result of ownership changes that could occur in the future pursuant to Internal Revenue Code Sections 382 and 383. These ownership changes may limit the amount of NOL and credit carryforwards that can be utilized to offset future taxable income and income tax, respectively. In general, an “ownership change” as defined by the tax code results from a transaction or series of transactions over a three-year period resulting in an ownership change of more than 50 percent of the outstanding stock of a company by certain stockholders or public groups. During 2020, the Company completed a study to assess whether an ownership change within the meaning of Section 382 had occurred for the time period prior to July 15, 2020. The study identified several such ownership changes during the study period, which resulted in limitations on the annual utilization of the Company’s NOL and credit carryforwards, or the “Tax Attribute” carryforwards; however, the study findings also indicated that none of the Company’s Tax Attribute carryforwards generated during the study period would expire solely as a result of annual limitations on the utilization of such Tax Attribute carryforwards. The Company updated the study for 2022 and did not identify any additional ownership changes. Future ownership changes could still occur which might place further limits on the Company’s ability to utilize its Tax Attribute carryforwards.

The Company’s federal income tax returns from 2020 forward, state income tax returns from 2019 forward, and its Australian tax returns beginning in 2021 are subject to examination by tax authorities; however, the Company's tax attribute carryforwards such as NOLs and R&D credits generated in closed tax years remain subject to adjustment by the taxing authorities until the future tax years in which those attributes are utilized are closed to statute. No such audits are underway.

Deferred tax assets and liabilities

Net deferred tax assets are comprised of the following as of December 31, 2023 and 2022 (in thousands):


	December 31,
	2023			2022
Deferred tax assets:
Net operating loss carryforwards	$	81,828		$	69,044
Capitalized research expenses		43,509			22,123
R&D and other tax credits		37,663			22,210
Stock-based compensation		12,207			8,168
Lease liabilities		10,889			648
Accrued expenses and other, net		5,350			4,208
Equity method investment		3,230			—
Total deferred tax assets		194,676			126,401
Deferred tax liabilities:
Right-of use assets		(9,799	)		(313	)
Equity method investment		—			(140	)
Net of deferred tax liabilities		(9,799	)		(453	)
Less: valuation allowance		(184,877	)		(125,948	)
Net deferred tax assets	$	—		$	—

Realization of deferred tax assets is dependent upon future earnings, if any, the timing and amount of which are uncertain. Management assesses the available positive and negative evidence to estimate if sufficient future taxable income will be

generated to use existing deferred tax assets. Based on the weight of available evidence, including the Company’s history of operating losses, management has determined that it is more likely than not that the Company’s net deferred tax assets will not be realized. Accordingly, a valuation allowance has been established by the Company to fully offset these net deferred tax assets.

Income tax benefit

For the three years in the period ended December 31, 2023, domestic and foreign pre-tax loss were (in thousands):


	Year ended December 31,
	2023			2022			2021
Loss before income taxes - Domestic	$	(214,027	)	$	(163,175	)	$	(107,723	)
Income (loss) before income taxes - Foreign		(502	)		(743	)		82
Loss before income taxes - Consolidated	$	(214,529	)	$	(163,918	)	$	(107,641	)


	Year ended December 31,
	2023			2022			2021
Expected income tax benefit at federal statutory rate	$	(45,051	)	$	(34,423	)	$	(22,605	)
State income tax benefit, net of federal benefit		(797	)		(128	)		(7,083	)
Tax effect of
Change in valuation allowance		59,951			39,733			34,495
R&D credit		(18,179	)		(10,918	)		(7,117	)
Stock-based compensation		1,241			781			1,196
Australian tax incentive		35			266			27
State rate change		44			3,243			(8	)
Uncertain tax positions		2,691			—			—
Other		65			1,446			1,095
Provision for income taxes	$	—		$	—		$	—

Changes to the Company’s unrecognized tax benefits are summarized in the following table (in thousands):


	Year ended December 31,
	2023		2022		2021
Beginning balance	$	4,110	$	1,553	$	1,092
Increase (decrease) for prior year tax positions		188		837		(34	)
Increase (decrease) for current year tax positions		2,648		1,720		495
Ending balance	$	6,946	$	4,110	$	1,553

Due to the existence of the valuation allowance, future changes in unrecognized tax benefits would not have any effect on the Company’s effective tax rate. The Company does not foresee any material changes to its unrecognized tax benefits within the next twelve months. There have been no decreases in unrecognized tax benefits due to settlements or expiration of statute of limitations for the assessment of taxes during the years ended December 31, 2023, 2022 and 2021.

The Company had no accrual for interest or penalties on its consolidated balance sheets as of December 31, 2023 or December 31, 2022, and has not recognized interest and/or penalties in its consolidated statements of operations for the years ended December 31, 2023, December 31, 2022, and December 31, 2021 as the unrecognized tax benefits relate to tax positions for which no cash tax liability has been reduced.

In response to the pandemic, the Coronavirus Aid, Relief and Economic Security Act (the “CARES Act”) was signed into law on March 27, 2020. The CARES Act, among other things, includes tax provisions relating to refundable payroll tax credits, deferment of employer’s social security payments, net operating loss utilization and carryback periods, modifications to the net interest deduction limitations and technical corrections to tax depreciation methods for qualified improvement property. The CARES Act did not have a material impact on our income tax provision for the year ended December 31, 2023, 2022, and 2021.

Deferred income taxes have not been provided for undistributed earnings of the Company’s consolidated foreign subsidiary because the Parent entity would not be required to include the distribution into income as the amount would be tax free.

The Tax Cuts and Jobs Act subjects a U.S. shareholder to tax on Global Intangible Low-Taxed Income ("GILTI") earned by certain foreign subsidiaries. The FASB Staff Q&A, Topic 740 No. 5. Accounting for Global Intangible Low-Taxed Income, states that an entity can make an accounting policy election to either recognize deferred taxes for temporary basis differences expected to reverse as GILTI in future years or to provide for the tax expense related to GILTI in the year the tax is incurred as a period expense only. We have elected to account for GILTI in the year the tax is incurred.

- Definition

The entire disclosure for income taxes. Disclosures may include net deferred tax liability or asset recognized in an enterprise's statement of financial position, net change during the year in the total valuation allowance, approximate tax effect of each type of temporary difference and carryforward that gives rise to a significant portion of deferred tax liabilities and deferred tax assets, utilization of a tax carryback, and tax uncertainties information.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Topic 946
-SubTopic 20
-Name Accounting Standards Codification
-Section 50
-Paragraph 13
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480990/946-20-50-13

Reference 2: http://www.xbrl.org/2003/role/disclosureRef
-Topic 235
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SX 210.4-08(h)(2))
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147480678/235-10-S99-1

Reference 3: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-Name Accounting Standards Codification
-Publisher FASB
-URI https://asc.fasb.org//740/tableOfContent

Reference 4: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 14
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482685/740-10-50-14

Reference 5: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 21
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482685/740-10-50-21

Reference 6: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 270
-Name Accounting Standards Codification
-Section 50
-Paragraph 1
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482526/740-270-50-1

Reference 7: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section 50
-Paragraph 17
-Subparagraph (b)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482685/740-10-50-17

Reference 8: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 1
-Subparagraph (SAB TOPIC 6.I.5.Q1)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479360/740-10-S99-1

Reference 9: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 10
-Name Accounting Standards Codification
-Section S99
-Paragraph 2
-Subparagraph (SAB Topic 11.C)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147479360/740-10-S99-2

Reference 10: http://www.xbrl.org/2003/role/disclosureRef
-Topic 740
-SubTopic 30
-Name Accounting Standards Codification
-Section 50
-Paragraph 2
-Subparagraph (a)
-Publisher FASB
-URI https://asc.fasb.org//1943274/2147482603/740-30-50-2

+ Details

Fair Value Measurements - Schedule of Financial Assets Measured at Fair Value on Recurring Basis (Details) - Fair Value, Measurements, Recurring - USD ($) $ in Thousands	Dec. 31, 2023	Dec. 31, 2022
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total assets measured at fair value		$ 302,421
Total Investment securities	$ 503,658	301,753
Level 1
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total assets measured at fair value		93,879
Total Investment securities	280,209	93,879
Level 2
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total assets measured at fair value		207,874
Total Investment securities	223,449	207,874
Level 3
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total assets measured at fair value		668
Total Investment securities	0
U.S. Government Obligations
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	280,209	93,879
U.S. Government Obligations \| Level 1
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	280,209	93,879
U.S. Government Obligations \| Level 2
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	0	0
U.S. Government Obligations \| Level 3
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	0	0
Agency obligations [member]
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	21,270	58,851
Agency obligations [member] \| Level 1
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	0	0
Agency obligations [member] \| Level 2
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	21,270	58,851
Agency obligations [member] \| Level 3
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	0	0
Certificates of Deposit
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	2,440	4,535
Certificates of Deposit \| Level 1
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	0	0
Certificates of Deposit \| Level 2
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	2,440	4,535
Certificates of Deposit \| Level 3
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	0	0
Commercial Paper
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	2,984
Commercial Paper \| Level 1
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	0
Commercial Paper \| Level 2
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	2,984
Commercial Paper \| Level 3
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	0
Corporate Debt Securities
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	196,755	142,994
Corporate Debt Securities \| Level 1
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	0	0
Corporate Debt Securities \| Level 2
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	196,755	142,994
Corporate Debt Securities \| Level 3
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities	$ 0	0
Asset-Backed Securities
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities		1,494
Asset-Backed Securities \| Level 1
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities		0
Asset-Backed Securities \| Level 2
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities		1,494
Asset-Backed Securities \| Level 3
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total Investment securities		0
Radionetics Warrant
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total assets measured at fair value		668
Radionetics Warrant \| Level 1
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total assets measured at fair value		0
Radionetics Warrant \| Level 2
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total assets measured at fair value		0
Radionetics Warrant \| Level 3
Fair Value Assets Measured On Recurring Basis Unobservable Input Reconciliation [Line Items]
Total assets measured at fair value		$ 668

Insider Trading Arrangements	3 Months Ended
Insider Trading Arrangements	Dec. 31, 2023 shares
Trading Arrangements, by Individual
Material Terms of Trading Arrangement	Rule 10b5-1 Trading Plans On December 20, 2023, Matthew Fust, a director on the Company’s board of directors, adopted a Rule 10b5-1 trading arrangement that is intended to satisfy the affirmative defense of Rule 10b5-1(c) for the sale of up to 60,000 shares of our common stock until December 20, 2024. None of our officers (as defined in Rule 16a–1(f)) or directors terminated any Rule 10b5-1 trading arrangement or non-Rule 10b5-1 trading arrangement, as each such term is defined in Item 408 of Regulation S-K.
Non-Rule 10b5-1 Arrangement Adopted	false
Rule 10b5-1 Arrangement Terminated	false
Matthew Fust [Member]
Trading Arrangements, by Individual
Name	Matthew Fust
Title	director
Rule 10b5-1 Arrangement Adopted	true
Non-Rule 10b5-1 Arrangement Adopted	false
Adoption Date	December 20, 2023
Aggregate Available	60,000
Expiration Date	December 20, 2024

Revenue Recognition - Additional Information (Details) - USD ($) $ in Thousands			1 Months Ended	12 Months Ended
	Mar. 24, 2023	Feb. 25, 2022	Oct. 31, 2021	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Revenue Recognition [Line Items]
Other Assets, Noncurrent				$ 2,000	$ 37
Upfront payment as license revenue				1,500	4,700
Upfront payment recognized as revenues				13,000
Revenues				4,013	4,737	$ 1,078
Five A M Ventures And Frazier Healthcare Partners [Member] \| Radionetics [Member]
Revenue Recognition [Line Items]
Sales and royalties milestones			$ 1,000,000
Sanwa Kagaku Kenkyusho Co Ltd
Revenue Recognition [Line Items]
Revenues				400	100
Sanwa Kagaku Kenkyusho Co Ltd \| Radionetics [Member]
Revenue Recognition [Line Items]
Sales and royalties milestones		$ 13,000
Non refundable, upfront payment		13,000
Additional milestone payments		$ 25,500
Cellular Longevity Inc doing business as Loyal [Member]
Revenue Recognition [Line Items]
Non refundable, upfront payment	$ 100
Revenues				2,100
Cellular Longevity Inc doing business as Loyal [Member] \| Convertible Preferred Stock [Member]
Revenue Recognition [Line Items]
Other Assets, Noncurrent				$ 2,000
Upfront payment	$ 2,000
Radionetics Oncology Inc [Member] \| Sanwa Kagaku Kenkyusho Co Ltd
Revenue Recognition [Line Items]
Revenues					$ 1,500

Equity Incentive Plans (Tables)

12 Months Ended

Dec. 31, 2023

Employee Stock Ownership Plan (ESOP) Disclosures [Line Items]

Summary of Activity Under Stock Option Plans

Activity under the Company’s stock option plans during the year ended December 31, 2023 was as follows:


				Weighted-		Weighted-		Aggregate
				Average		Average		Intrinsic
	Options			Exercise		Remaining		Value
	Outstanding			Price		Term (in years)		(000’s)
Balance on December 31, 2022		9,757,329		$	17.79
Granted		4,824,597		$	20.67
Exercised		(1,282,603	)	$	15.66
Forfeited and expired		(672,199	)	$	20.56
Balance on December 31, 2023		12,627,124		$	18.96		8.0	$	209,884
Vested and expected to vest on December 31, 2023		12,627,124		$	18.96		8.0	$	209,884
Exercisable on December 31, 2023		5,255,484		$	17.36		6.7	$	95,731

Summary of Company's restricted stock unit activity

The Company’s restricted stock unit activity during the year ended December 31, 2023 was as follows:


				Weighted-
	Restricted Stock			Average
	Units			Grant Date
	Outstanding			Fair Value
Balance on December 31, 2022		290,311		$	19.88
Granted		666,621		$	19.62
Vested		(81,294	)	$	19.54
Forfeited		(62,004	)	$	19.77
Balance on December 31, 2023		813,634		$	19.71

Weighted Average Assumptions Used to Estimate Fair Value of Stock Options Granted to Employees

The following table summarizes the weighted average assumptions used to estimate the fair value of stock options granted under the Company’s stock option plans for the periods presented below:


Stock Option Awards	Year ended December 31,
	2023			2022			2021
Expected option term	6.0 years			6.1 years			6.0 years
Expected volatility		66	%		88	%		86	%
Risk free interest rate		4.1	%		2.8	%		1.0	%
Expected dividend yield		—	%		—	%		—	%

Summary of Stock-based Compensation Expense for the Equity Awards Issued to Employees and Non-Employees

Stock-based compensation expense for the equity awards issued by the Company to employees and non-employees for the periods presented below was as follows (in thousands):


	Year ended December 31,
	2023		2022		2021
Included in research and development	$	22,633	$	15,078	$	9,654
Included in general and administrative		18,304		13,190		7,698
Total stock-based compensation expense	$	40,937	$	28,268	$	17,352

Employee Stock Purchase Plan [Member]

Employee Stock Ownership Plan (ESOP) Disclosures [Line Items]

Weighted Average Assumptions Used to Estimate Fair Value of Stock Options Granted to Employees

The following table summarizes the weighted average assumptions used to estimate the fair value of the ESPP awards for the periods presented below:


ESPP	Year ended December 31,
	2023			2022			2021
Expected term	1.1 years			1.3 years			1.6 years
Expected volatility		66	%		87	%		91	%
Risk free interest rate		5.0	%		4.1	%		0.3	%
Expected dividend yield		—	%		—	%		—	%

Equity Incentive Plans - Stock-based Compensation Expense Recognized (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022	Dec. 31, 2021
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense	$ 40,937	$ 28,268	$ 17,352
Included in Research and Development
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense	22,633	15,078	9,654
Included in General and Administrative
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
Stock-based compensation expense	$ 18,304	$ 13,190	$ 7,698

Investment In Radionetics

12 Months Ended

Dec. 31, 2023

Schedule of Investments [Abstract]

INVESTMENT IN RADIONETICS

9. INVESTMENT IN RADIONETICS

The Radionetics License

In October 2021, the Company entered into a Collaboration and License Agreement with Radionetics (the "Radionetics License") in which the Company granted Radionetics an exclusive worldwide license to its technology for the development of radiotherapeutics and related radio-imaging agents in exchange for 50,500,000 shares of common stock of Radionetics, which represented an initial majority stake in Radionetics of 64%, and the Radionetics Warrant to purchase the greater of 3,407,285 additional shares of Radionetics common stock or the number of additional shares of Radionetics common stock that would allow the Company to maintain an aggregate equity interest of 22% of the fully diluted capitalization of Radionetics.

The upfront noncash consideration was valued at $1.1 million, which was comprised of $1.0 million for the Company's share of Radionetics common stock and $0.1 million for the Radionetics Warrant. The Radionetics License is for functional intellectual property which was transferred at the inception of the Radionetics License. The Company does not have an ongoing performance obligation to support or maintain the licensed intellectual property under the Radionetics License. In October 2021, the entire amount of the upfront noncash consideration of $1.1 million was recognized as license revenue in accompanying consolidated statements of operations and comprehensive loss upon the Company's transfer of the license under the Radionetics License.

In addition to the upfront non-cash considerations, the Company may receive potential sales milestones in excess of $1.0 billion and single-digit royalties on net sales. As there have been no sales to date, no sales-based milestones or royalties were recognized to date.

The Company engaged a third-party valuation specialist to assist the Company with its determination of the estimated fair value of these upfront noncash considerations received. A cost approach was utilized to determine the implied value of Radionetics’ equity since it was newly formed with early development stage technology from the Radionetics License for which there are not reliable long-term forecasts. Next, the total equity value was allocated to various share classes using the current value method and option pricing method. The current value method allocates the value of the business to the shareholders' given consideration of senior obligations such as debt, equity certificates and other preferred equity. The option pricing method entails allocating the total shareholders’ equity value to the various share classes based upon their respective claims on a series of call options with strike prices at various value levels depending upon the rights and preferences of each class.

The primary inputs used in valuing the Radionetics common stock and the Radionetics Warrant, were as follows:


Derivative Asset	December 31, 2022			October 15, 2021 and December 31, 2021
Expected term	1.8 years			3.0 years
Expected volatility		116.6	%		111.4	%
Risk free interest rate		4.5	%		0.7	%
Marketability discount		51.0	%		30.0	%

The Company estimated the expected term based on the expected time to a liquidity event. The risk-free interest rate was based on the yields of zero-coupon U.S. treasury securities. Volatility was estimated based upon an analysis of historical equity and asset volatilities of companies deemed comparable to Radionetics. The valuation amounts were adjusted by a discount for lack of marketability to account for the lack of liquidity an owner of the interest would experience for common stock in an early-stage company. The estimated value for the common stock of Radionetics and the Radionetics Warrant was $0.02 per share as of October 15, 2021 and December 31, 2021 and $0.20 per share as of December 31, 2022. In August 2023, the Company exercised the Radionetics Warrant to purchase 3,407,285 shares of Radionetics common stock with an exercise price of $0.00001 per share.

Investment in Radionetics

Radionetics is a VIE due to having insufficient equity to finance its activities without additional subordinated financial support. The Company evaluated whether it is the primary beneficiary of Radionetics by evaluating Radionetics’ key activities: (1) conducting research and development, (2) making financing decisions, and (3) determining the strategic direction of Radionetics. Decisions about research and development activities are made by unanimous vote of members of the research and development committee, in which no individual party has unilateral decision making power. Decisions about financing and strategic direction rest with Radionetics’ board of directors, and no party was determined to be in control, given the Radionetics board of directors was comprised of three members for which each of Crinetics, 5AM and Frazier were entitled to appoint and replace, as needed, their board designee, and a fourth member mutually agreed upon by the other three board members. Radionetics’ management was separate from the Company and was determined by Radionetics’ board of directors. As the Company did not control any of Radionetics' key activities, it was not the primary beneficiary of the VIE and did not consolidate the financial results of Radionetics.

The Company accounts for its investment in Radionetics common stock under the equity method of accounting due to its ability to exercise significant influence. The Company records its share of Radionetics income (loss) outside of operations in the statements of operations and comprehensive loss on a quarterly lag. The Company's equity method investment in Radionetics was written down to zero during the first quarter of 2022 as a result of the allocation of the Company’s share of losses of the investee.

In August 2023, Radionetics completed a financing (the “August 2023 Radionetics Transaction”) pursuant to which (1) the Company exercised the Radionetics Warrant to purchase 3,407,285 shares of Radionetics common stock with an exercise price of $0.00001 per share, (2) the Company exchanged 32,344,371 shares of Radionetics common stock for Radionetics

preferred stock on a one-for-one basis, (3) the Company invested $5.0 million to purchase 14,404,656 shares of preferred stock in Radionetics along with other new and existing investors who participated in the financing, and (4) the Company and Radionetics agreed to amend the Radionetics License to include additional sales milestones of up to $15 million. In connection with the August 2023 Radionetics Transaction, Radionetics’ convertible notes held by other investors were converted to Radionetics preferred stock and certain shares of Radionetics common stock held by other investors were cancelled.

The August 2023 Radionetics Transaction was a VIE reconsideration event. The Company determined that Radionetics continues to be a VIE due to Radionetics having insufficient equity to finance its activities without additional subordinated financial support. The Company also reevaluated whether it is the primary beneficiary of Radionetics and noted there were no changes to Radionetics’ key activities or the conclusion that the Company does not control any of these activities. The size of Radionetics’ board of directors was increased from four to six members. Crinetics, 5AM and Frazier are each entitled to appoint and replace, as needed, their board designee, the fourth member is Radionetics’ CEO, and the fifth and sixth members must be mutually agreed upon by the other four board members. All changes to board composition are subject to shareholder approval with common and preferred shareholders having equal votes. Radionetics’ management continues to be entirely separate from the Company and determined by the Radionetics’ board of directors. As the Company does not control any of Radionetics' key activities, it is not the primary beneficiary and does not consolidate the financial results of Radionetics. Accordingly, the Company continues to account for its investment in Radionetics under the equity method of accounting due to its ability to exercise significant influence.

The Company determined that its preferred stock investment in Radionetics represents in-substance common stock. The preferred stock investment is substantially similar to common stock in that it does not have a substantive liquidation preference since the preferred stock will participate in substantially all of Radionetics losses, the conversion ratio for preferred stock into common stock is on a one-for-one basis without any significant restrictions or contingencies, and the preferred stock lacks redemption features, among other factors.

The Company is not obligated to fund losses incurred by Radionetics. The Company’s $5.0 million purchase of preferred stock in the August 2023 Radionetics Transaction was alongside new and existing investors and did not fund previous losses.

In connection with the August 2023 Radionetics Transaction, the Company exercised the Radionetics Warrant, which had a fair value of $0.7 million, and purchased $5.0 million of preferred stock. These transactions resulted in a $5.7 million increase in the Company’s investment in Radionetics. As a result of the August 2023 Radionetics Transaction, the Company experienced net dilution in its ownership of Radionetics from a 55% ownership stake in Radionetics common stock to a 31% combined ownership stake in Radionetics common and preferred stock. No gain was recorded upon dilution since cumulative losses that had been suspended exceeded the gain on dilution.

The amendment to the Radionetics License in connection with the August 2023 Radionetics Transaction did not result in additional revenue at the time of modification and the sales-based milestones and royalty payments will only be recognized when the milestones or sales occur.

In December 2023, Radionetics completed a financing to sell additional shares of preferred stock to new and existing investors (the “December 2023 Radionetics Transaction”). The Company continues to maintain significant influence and accounts for its investment in Radionetics under the equity method of accounting. As a result of the December 2023 Radionetics Transaction, the Company experienced net dilution in its ownership of Radionetics from a 31% ownership stake in Radionetics common and preferred stock to a 26% combined ownership stake in Radionetics common and preferred stock. No gain was recorded upon dilution since cumulative losses that had been suspended exceeded the gain on dilution.

During the years ended December 31, 2023 and 2022, the Company recorded equity method losses of $5.2 million and $1.0 million, respectively, in the accompanying consolidated statements of operations and comprehensive loss, as a result of the allocation of the Company’s share of Radionetics eligible losses, which is recorded on a quarterly lag. As of December 31, 2023, the Company’s investment in Radionetics of $0.5 million is recorded as a long-term asset in the accompanying consolidated balance sheets.

Other Items

R. Scott Struthers, Ph.D., the Company’s President and Chief Executive Officer, serves as chairman of the Radionetics board of directors. Pursuant to such arrangement, in October 2021, Dr. Struthers received 1,000,000 shares of restricted common stock of Radionetics, which vest ratably over 36 months, subject to continued service, and Dr. Struthers receives a $50,000 annual retainer for his service as a board member of Radionetics.

As of December 31, 2023 and 2022, the Company had $0.1 million due from Radionetics for reimbursement of certain expenses paid on behalf of Radionetics. These amounts are recorded within prepaid expenses and other current assets in the

accompanying consolidated balance sheets. During the years ended December 31, 2023, 2022 and 2021, the Company received reimbursements from Radionetics of $0.1 million, $0.4 million, and $0.6 million, respectively.

Operating Lease (Tables)

12 Months Ended

Dec. 31, 2023

Leases [Abstract]

Schedule of Future Minimum Payments Under Non-cancellable Operating Leases

As of December 31, 2023, the Company's future minimum payments under non-cancellable operating leases, were as follows (in thousands):


Year ending December 31,	Minimum Payments
2024	$	4,491
2025		7,468
2026		6,795
2027		6,999
2028		7,209
Thereafter		50,975
Total future minimum lease payments		83,937
Less imputed interest		(32,209	)
Total operating lease liabilities		51,728
Less operating lease liabilities, current		(4,173	)
Operating lease liabilities, non-current	$	47,555