United States securities and exchange commission logo

                     April 4, 2023

       Marc J.S. Wilson
       Chief Financial Officer
       Crinetics Pharmaceuticals, Inc.
       10222 Barnes Canyon Road
       Bldg. #2
       San Diego, California 92121

                                                        Re: Crinetics
Pharmaceuticals, Inc.
                                                            Form 10-K for
Fiscal Year Ended December 31, 2021
                                                            Filed March 30,
                                                            File No. 001-38583

       Dear Marc J.S. Wilson:

              We have completed our review of your filing. We remind you that
the company and its
       management are responsible for the accuracy and adequacy of their
disclosures, notwithstanding
       any review, comments, action or absence of action by the staff.


                     Division of Corporation Finance

                     Office of Life Sciences